“…Two approaches are considered to define a CADe (see Table 6): (i) voxel-based delineation and (ii) lesion segmentation. The first strategy, which concerns the majority of the studies reviewed (see Table 6), is in fact linked to the nature of the classification framework [114,115,163,128,166,104,135,167,98,99,126,168,169,170,151,171,172,132,173,174,145,110,118,119]. All voxels are considered as a possible lesion and the output of the framework will be pixels classified as lesion and non lesion.…”