Prostate cancer recurring as small‐cell carcinoma with a <scp><i>BRCA2</i></scp> somatic mutation

Yabusaki, Ryo; Yoshimura, Koji; Taku, Keisei; Suzuki, Makoto

doi:10.1002/iju5.12523

Cited by 1 publication

(2 citation statements)

References 18 publications

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“…We speculate that although higher grade tumors are more likely to metastasize, that does not necessarily mean that they will spread to atypical locations. Inguinal LN metastases were seen throughout grade groups 1–5 in our study, as has been described in case reports ( 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ) . In two cohorts of patients with predominantly high-grade group PCa who underwent dissection of pelvic LNs, metastasis in deep inguinal LNs was confirmed on pathology in only one (2.6%) and three (1.1%) of the 39 and 285 patients in each cohort, respectively ( 28 , 29 ) .…”

Section: Discussionsupporting

confidence: 89%

“…Recently, Schiller et al ( 4 ) investigated 799 LNs in 233 patients who underwent prostatespecific membrane antigen positron-emission tomography/computed tomography (PSMA PET/CT) and found that 10 inguinal LNs (1.3%) were suspicious (i.e., “PET-positive”), although there was again no verification by pathology. The remainder of the literature consists of a few case reports in which investigators raise hypotheses on potential pathways for the spread to inguinal LNs, such as altered lymphatic drainage after prostatectomy ( 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ) . In clinical practice, questions regarding abnormal inguinal LNs raising concern for metastases are becoming increasingly common, especially with the growing popularity of molecular imaging (e.g., PSMA PET/CT).…”

Section: Introductionmentioning

confidence: 99%

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Inguinal lymph node metastases from prostate cancer: clinical, pathology, and multimodality imaging considerations

Woo,

Becker,

Ghafoor

et al. 2024

Radiol Bras

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Objective: To investigate clinical, pathology, and imaging findings associated with inguinal lymph node (LN) metastases in patients with prostate cancer (PCa). Materials and Methods: This was a retrospective single-center study of patients with PCa who underwent imaging and inguinal LN biopsy between 2000 and 2023. We assessed the following aspects on multimodality imaging: inguinal LN morphology; extrainguinal lymphadenopathy; the extent of primary and recurrent tumors; and non-nodal metastases. Imaging, clinical, and pathology features were compared between patients with and without metastatic inguinal LNs. Results: We evaluated 79 patients, of whom 38 (48.1%) had pathology-proven inguinal LN metastasis. Certain imaging aspects— short-axis diameter, prostate-specific membrane antigen uptake on positron-emission tomography, membranous urethra involvement by the tumor, extra-inguinal lymphadenopathy, and distant metastases—were associated with pathology-proven inguinal LN metastases (p < 0.01 for all). Associations with long-axis diameter, fatty hilum, laterality, and uptake of other tracers on positronemission tomography were not significant (p = 0.09–1.00). The patients with metastatic inguinal LNs had higher prostate-specific antigen levels and more commonly had castration-resistant PCa (p < 0.01), whereas age, histological grade, and treatment type were not significant factors (p = 0.07–0.37). None of the patients had inguinal LN metastasis in the absence of locally advanced disease with membranous urethra involvement or distant metastasis. Conclusion: Several imaging, clinical, and pathology features are associated with inguinal LN metastases in patients with PCa. Isolated metastasis to inguinal LNs is extremely rare and unlikely to occur in the absence of high-risk imaging, clinical, or pathology features.

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