Prostate cancer recurrence after radical prostatectomy: the role of 3-T diffusion imaging in multi-parametric magnetic resonance imaging

Panebianco, Valeria; Barchetti, Flavio; Sciarra, Alessandro; Musio, Daniela; Forte, Valerio; Gentile, Vincenzo; Tombolini, Vincenzo; Catalano, Carlo

doi:10.1007/s00330-013-2768-3

Cited by 133 publications

(108 citation statements)

References 29 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent literature on the topic shows that local recurrence was detected in larger series at a PSA level of around 0.8-1.3 ng/ml (45,46). Cirillo and coworkers estimated sensitivity of 84% and specificity of 89% in patients with a PSA level of ~1.2 ng/ml (35).…”

Section: Discussionmentioning

confidence: 99%

Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Buergy

Sertdemir²,

Weidner

et al. 2018

View full text Add to dashboard Cite

Abstract. Background Prostate carcinoma is the second most common cancer in males (1) and although mortality rates have decreased in European countries and the United States (US), it still accounts for more than 258,000 deaths worldwide (2). According to the USpopulation-based Surveillance, Epidemiology, and End Results Program database, ~80% of men with newly diagnosed prostate carcinoma had localized disease at the time of diagnosis (3). Most of these patients selected radical prostatectomy or external beam radiotherapy as their primary treatment option (4,5). Recurrence rates after radical prostatectomy differ widely between around 10% of patients and more than 30% within 5 years (6-8), depending on Gleason score and other risk factors (6). In patients with positive surgical margins, it can be estimated that 20-40% of tumors recur (9, 10) and the majority of patients with biochemical relapse are diagnosed as having local recurrence (11). Radiotherapy as salvage treatment has been shown to improve biochemical control in patients with residual disease or biochemical relapse (12, 13). Stephenson et al. estimated that biochemical control can be achieved by radiotherapy in 48% of patients when salvage treatment starts before the prostatespecific antigen (PSA) level reaches 0.5 ng/ml; if administered at a PSA level of 0.5 ng/ml and above, only 26% of patients treated were free from (further) relapse (14). These results have been confirmed by modern series which additionally showed a clinical benefit in terms of distant metastasis-free survival, disease-specific mortality, and all-cause mortality (15). Furthermore, modern series indicated early salvage radiotherapy, initiated at the earliest sign of measurable PSA, to be beneficial in terms of biochemical and clinical endpoints (15, 16). Severe toxicity of salvage radiotherapy is generally reported to be low (17) but even in modern series, there is a residual risk of grade 3/4 bowel or urinary toxicity (18). 125This article is freely accessible online. (28,29). In a comparative study (29), radiotherapy plans contoured according to consensus guidelines failed to meet QUANTEC (30), and RADICALS (31) trial dose constraints in 75%, and 40% of cases, respectively. These inconsistencies indicate that our current approaches to salvage treatment of prostate carcinoma after radical prostatectomy should be reassessed. Improvement of therapeutic efficacy could be achieved by reducing geographical miss and side-effects by accurate detection of residual disease.Detection of residual prostate carcinoma is possible by magnetic resonance imaging (MRI) and positron-emission tomography-computed tomography (PET-CT). Evidence on restaging of biochemically relapsed patients with PET-CT was recently reviewed by Umbehr et al. (32). The authors analyzed 12 studies and found a pooled sensitivity and specificity of 85%, and 88%, respectively (mean PSA=7.9 ng/ml). In patients with early relapse (PSA <1 ng/ml), however, the authors found no convincing evidence for the use of PET-CT.MRI with (...

show abstract

Section: Discussionmentioning

confidence: 99%

Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Buergy

Sertdemir²,

Weidner

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Cependant dans cette étude la dimension des récidives était supé-rieure à 1,5 cm pour un PSA de 1,23 ± 1,3 ng/mL. Dans une étude récente, Panebianco et al retrouvent une sensibilité et une spécificité de 98 % et 94 % pour la détection d'une récidive locale en associant la séquence morphologique et la séquence de perfusion pour une valeur de PSA moyen de 1,3 ng/mL (0,5-1,7 ng/mL) et une dimension moyenne de 5 ± 0,6 mm (4-8 mm) [7] Les séquences de diffusion sont également informatives, notamment avec l'utilisation de valeurs de b élevées à 3 T (supérieures à 1000 s/mm 2 et pouvant atteindre 3000 s/mm 2 ). Cependant elles sont souvent difficiles d'interprétation en raison d'artefacts dus aux mouvements digestifs [7].…”

Section: Aspect De La Récidive Séquences Fonctionnellesunclassified

Imagerie post-thérapeutique du cancer de la prostate

Renard-Penna

Michaud

Cormier

et al. 2015

Progrès en Urologie

View full text Add to dashboard Cite

“…43 Multiparametric imaging has well-recognized utility for microstructural and vascular tissue characterization and is rapidly establishing an expanding niche in the localization and management of prostate cancer. 44, 45 Yet, in general, it remains more difficult to assess metabolic activity with MRI than with PET; MR spectroscopy (MRS) is inconsistently used in clinics, as it requires significant expertise in acquisition and processing of the MR signal; whilst hyperpolarized (HP) MRI in addition requires significant investment in infrastructure. Studies validating the use of whole-body PET/MR compared with PET/CT have repeatedly shown increased sensitivity in early tumour detection, and using diffusion weighting on top of PET/MR can also detect treatment response at varying levels within metastases.…”

Section: 36mentioning

confidence: 99%

The use of molecular imaging combined with genomic techniques to understand the heterogeneity in cancer metastasis

Chowdhury¹,

Ganeshan²,

Irshad³

et al. 2014

BJR|case reports

View full text Add to dashboard Cite

Prostate cancer recurrence after radical prostatectomy: the role of 3-T diffusion imaging in multi-parametric magnetic resonance imaging

Cited by 133 publications

References 29 publications

Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Detection of Local Recurrence with 3-Tesla MRI After Radical Prostatectomy: A Useful Method for Radiation Treatment Planning?

Imagerie post-thérapeutique du cancer de la prostate

The use of molecular imaging combined with genomic techniques to understand the heterogeneity in cancer metastasis

Contact Info

Product

Resources

About