Prostate Cancer: Multiparametric MRI for Index Lesion Localization—A Multiple-Reader Study

Rosenkrantz, Andrew B.; Deng, Fang; Kim, Sooah; Lim, Ruth; Hindman, Nicole; Mussi, Thais C.; Spieler, Bradley; Oaks, J. Lindsay; Babb, James S.; Melamed, Jonathan; Taneja, Samir S.

doi:10.2214/ajr.11.8446

Cited by 72 publications

(45 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Because of the small survival benefit reported for radical prostatectomy (RP) and the generally excellent natural history reported in the series of PCa patients treated with active surveillance, there is an increasing interest in minimally invasive focal therapy or active surveillance strategies (Rosenkrantz et al 2012). However, current clinical paradigms used to stratify patients into risk categories, including digital rectal examination results, PSA values, and the results of transrectal ultrasound guided biopsies, among others, are affected by intrinsic errors and possible complications (Gupta et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Texture features on T2-weighted magnetic resonance imaging: new potential biomarkers for prostate cancer aggressiveness

Vignati¹,

Mazzetti²,

Giannini³

et al. 2015

Phys. Med. Biol.

106

View full text Add to dashboard Cite

To explore contrast (C) and homogeneity (H) gray-level co-occurrence matrix texture features on T2-weighted (T2w) Magnetic Resonance (MR) images and apparent diffusion coefficient (ADC) maps for predicting prostate cancer (PCa) aggressiveness, and to compare them with traditional ADC metrics for differentiating low-from intermediate/high-grade PCas.The local Ethics Committee approved this prospective study of 93 patients (median age, 65 years), who underwent 1.5 T multiparametric endorectal MR imaging before prostatectomy. Clinically significant (volume ≥0.5 ml) peripheral tumours were outlined on histological sections, contoured on T2w and ADC images, and their pathological Gleason Score (pGS) was recorded. C, H, and traditional ADC metrics (mean, median, 10th and 25th percentile) were calculated on the largest lesion slice, and correlated with the pGS through the Spearman correlation coefficient. The area under the receiver operating characteristic curve (AUC) assessed how parameters differentiate pGS = 6 from pGS ≥ 7.The

show abstract

Section: Introductionmentioning

confidence: 99%

Texture features on T2-weighted magnetic resonance imaging: new potential biomarkers for prostate cancer aggressiveness

Vignati¹,

Mazzetti²,

Giannini³

et al. 2015

Phys. Med. Biol.

106

View full text Add to dashboard Cite

show abstract

“…Another study [24] investigating the diagnostic performance of images acquired without an ERC found that index lesions can be detected with an average sensitivity…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A Multicenter Study

Barth¹,

Rupp²,

Cornelius³

et al. 2019

Current Urology

View full text Add to dashboard Cite

Introduction: The purpose of this study was to compare diagnostic accuracy of a prostate multiparametric magnetic resonance imaging (mpMRI) protocol for detection of prostate cancer between images acquired with and without en-dorectal coil (ERC). Materials: This study was approved by the regional ethics committee. Between 2014 and 2015, 33 patients (median age 51.3 years; range 42.1-77.3 years) who underwent prostate-MRI at 3T scanners at 2 different institutions, acquired with (mpMRI_ERC) and without (mpMRI_PPA) ERC and who received radical prostatectomy, were included in this retrospective study. Two expert readers (R1, R2) attributed a PI-RADS version 2 score for the most suspect (i. e. index) lesion for mpMRI_PPA and mpMRI_ERC. Sensitivity and positive predictive value for detection of index lesions were assessed using 2 × 2 contingency tables. Differences between groups were tested using the McNemar test. Whole-mount histopathology served as reference standard. Results: On a quadrant-basis cumulative sensitivity ranged between 0.61-0.67 and 0.76-0.88 for mpMRI_PPA and mpMRI_ERC protocols, respectively (p > 0.05). Cumulative positive predictive value ranged between 0.80-0.81 and 0.89-0.91 for mpMRI_PPA and mpMRI_ERC protocols, respectively. The differences were not statistically significant for R1 (p = 0.267) or R2 (p = 0.508). Conclusion: Our results suggest that there may be no significant differences for detection of prostate cancer between images acquired with and without an ERC.

show abstract

“…van den Bos et al [3] recommends the inclusion of MRI before considering the FT, due to the high negative predictive value (up to 95%) for clinically significant tumours [27]. Rosenkrantz et al [28] described the usefulness of MRI in the localization of the IL, with a positive predictive value of 65.3% and a sensitivity of 60.2%. However, these data are not reached by all groups and there is a high inter- and intraobserver variability rate that may lead to the under- or overestimation of the cancer stage [27].…”

Section: Discussionmentioning

confidence: 99%

Twelve Core Template Prostate Biopsy is an Unreliable Tool to Select Patients Eligible for Focal Therapy

Fumadó¹,

Rosell²,

Juanpere³

et al. 2015

Urol Int

View full text Add to dashboard Cite

Introduction: To determine whether unilateral prostate cancer diagnosed at 12-core prostate biopsy harbours relevant prostate cancer foci in contralateral lobe in cases eligible for hemiablative focal therapy. Material and Methods: We analysed 112 radical prostatectomies of unilateral Gleason 6/7 prostate cancer based on prostate biopsy information. The presence of significant prostate cancer foci and/or the index lesion in the contralateral lobe is described. A subanalysis is performed in cases of Gleason score 6 and in cases of very-low-risk prostate cancer. Results: Contralateral prostate cancer was present in 69.6% of cases, fulfilling significant prostate cancer criteria in 33% and being the index lesion in 32%. No significant differences were found when analysing the Gleason 6 group (73% contralateral prostate cancer, 34% significant prostate cancer and 35% index lesion) or the very-low-risk prostate cancer group (80% contralateral prostate cancer, 29% significant prostate cancer and 45% index lesion). Conclusions: The assumption of unilateral prostate cancer based on 12-core template prostate biopsy information is unreliable. In about one third of the cases, there will be focus of significant prostate cancer or the index lesion in the contralateral lobe. This information should be taken into account when hemiablative focal therapies are considered.

show abstract

Prostate Cancer: Multiparametric MRI for Index Lesion Localization—A Multiple-Reader Study

Abstract: The sensitivity and PPV of multiparametric MRI for index lesion localization were moderate, although they improved in the setting of more aggressive pathologic features and a greater number of abnormal MRI parameters, respectively.

Cited by 72 publications

References 55 publications

Texture features on T2-weighted magnetic resonance imaging: new potential biomarkers for prostate cancer aggressiveness

Texture features on T2-weighted magnetic resonance imaging: new potential biomarkers for prostate cancer aggressiveness

Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A Multicenter Study

Twelve Core Template Prostate Biopsy is an Unreliable Tool to Select Patients Eligible for Focal Therapy

Contact Info

Product

Resources

About