Prostate cancer metastasis to the distal phalanx of the left hallux: The first confirmed case and literature review

Abstract

Abstract. Prostate cancer is one of the most common carcinomas in Asia, as well as all over the world. The vast majority of prostate cancer patients present with bone metastases, which mainly involve the axial bones, with pain as the most common symptom. The present study reports the first case of prostate cancer metastasis to the hallux in a 73-year-old man who presented with pain and a swollen phalanx of the left hallux. This symptom developed gradually over a period of several months and could not be improved with the common treatments. Due to a pathological fracture, amputation of the left phalanx was performed. Notably, the immunohistochemical examinations of the surgical sample demonstrated the presence of a metastatic lesion from prostate cancer. The present study describes an unusual presentation involving phalangeal metastasis in a prostate cancer patient, and a systematic review of reported cases of rare metastatic events in prostate cancer is also discussed.

Metastatic prostate carcinoma: A rare presentation initially misdiagnosed as a rib fracture

“…In conclusion, primary prostate carcinoma presenting as solitary metastatic osteolytic lesion is extremely uncommon [4] , [5] , [6] . This case is the first reported that initially presented as a pathologic fracture of a rib.…”

“…This patient presented with progressive severe hip stiffness and pain [5] . There has also been a report of a single osteolytic lesion as the presenting finding for metastatic prostate carcinoma in the left hallux distal phalanx [6] . We present a documented and confirmed case of a solitary osteolytic bone lesion from metastatic prostate carcinoma and per our literature review the first such lesion described in the rib.…”

A Case of Metastatic Prostate Cancer to the Distal Phalanx

“…In addition, within the literature, Sui et al 7 was the first to report the finding of prostate cancer metastasis to the distal phalanx of the left hallux in a case report in 2016. Their patient developed lung and vertebral bone metastases 1 year after initial prostate cancer diagnosis.…”