Prostate Cancer: Diagnostic Performance of Real-time Shear-Wave Elastography

Abstract

Use of a 35-kPa threshold at SWE may provide additional information for the detection and biopsy guidance of prostate cancer, enabling a substantial reduction in the number of biopsies while ensuring that few peripheral zone adenocarcinomas are missed.

Comparison of meta-analyses among elastosonography (ES) and positron emission tomography/computed tomography (PET/CT) imaging techniques in the application of prostate cancer diagnosis

“…In the process of recognizing and selecting associated studies with 11C-choline PET/CT [5,[8][9][10], 18F-FCH PET/ CT [20,44,[49][50][51][52][53][54][55][56][57][58][59][60][61], 11C-acetate PET/CT [7,13,14,62,63], 18F-FDG PET/CT [64][65][66][67][68], TRTE [11,12,[69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88], and SWE [3,…”

“…Specifically, TRTE and SWE could highlight morphologic and biomechanical discrepancies between PCa positive and negative tissues on the basis of ultrasonoscopy [3], while PET/CT might reflect distinctions of metabolic activities inside human body through showing the aggregate state of glucose, protein, nucleic acid, and fatty acid labeled by radiotracers, such as 18F-2-deoxy-2-fluoro-Dglucose (FDG) [4], 11C-choline [5], 18F-fluorocholine (FCH) [6], 11C-acetate [7], and so on.…”

Novel application of three-dimensional shear wave elastography in the detection of clinically significant prostate cancer

“…Ahmad et al (19) reported that data analyzed per core regarding SWE findings indicated that for patients with serum PSA <20 ng/ml, the sensitivity and specificity of SWE for prostate cancer detection were 90 and 88%, respectively, while in patients with PSA >20 ng/ml, the sensitivity and specificity were 93 and 93%, respectively. Correas et al (20) reported that the sensitivity, specificity, PPV, NPV and AUC for SWE with a cut-off of 35 kPa for differentiating benign from malignant lesions in 1,040 peripheral zone sextants from 184 patients were 96% (95% CI: 95-97), 85% (95% CI: 83-87), 48% (95% CI: 46-50), 99% (95% CI: 98-100) and 95% (95% CI: 93-97), respectively. In the present study, when combining the cut-off value of 41.0 kPa for tissue elasticity to PI-RADS score, the sensitivity, specificity, PPV and NPV of cancer detection were 70, 98, 91 and 92%, respectively.…”

“…Previous reports have indicated the clinical applications of SWE (19,20). Ahmad et al (19) reported that data analyzed per core regarding SWE findings indicated that for patients with serum PSA <20 ng/ml, the sensitivity and specificity of SWE for prostate cancer detection were 90 and 88%, respectively, while in patients with PSA >20 ng/ml, the sensitivity and specificity were 93 and 93%, respectively.…”

Aim: To investigate the value of ElastPQ measurement for differential diagnosis of benign and malignant focal liver lesions (FLLs) by using histologic results as a reference standard. Material and methods: A total of 154 patients were included. ElastPQ measurement was performed for each lesion in which the shear wave speed (SWS) was measured. The difference in SWS and SWS ratio of FLL to surrounding liver were evaluated, and the cut off value was investigated. Receiver operating characteristic (ROC) curve

“…It enjoys high levels of intraobserver and interobserver agreement [6]. PSWE has been reported to be useful in noninvasively diagnosis and characterization of different solid tumors, which have been found to be stiffer than the surrounding tissues: e.g., breast lesions [7], prostate cancer [8], thyroid cancer [9], lymph nodes [10] and pancreatic masses [11]. Beyond CEUS, CT or MRI, it may help discriminating malignant versus benign masses, particularly with regard to patients unsuitable for contrast enhanced imaging [12].…”