Prostate cancer detection among readers with different degree of experience using ultra-high b-value diffusion-weighted Imaging: Is a non-contrast protocol sufficient to detect significant cancer?

Abstract

• Significant prostate cancer using zoomed ultra-high b-value DWI was detected. • Diagnostic performance among readers with different degrees of experience was good. • mp- MRI of the prostate using a comprehensive non-contrast protocol is clinically feasible.

Biparametric vs multiparametric prostate magnetic resonance imaging for the detection of prostate cancer in treatment‐naïve patients: a diagnostic test accuracy systematic review and meta‐analysis

“…An initial 3502 studies underwent title and abstract screening, of which 127 studies were retrieved for full‐text review. In all, 31 studies reporting on 9480 patients (4296 with prostate cancer) met the inclusion criteria for meta‐analysis; 25 studies reported on mpMRI DTA (7000 patients, 2954 with prostate cancer), 12 studies reported on bpMRI DTA (2716 patients, 1477 with prostate cancer), and six studies directly compared mpMRI and bpMRI (2047 patients, 1063 with prostate cancer). Table provides a summary of the included studies [22,34––63], while Table provides a risk of bias summary of the included studies [22,34––63].…”

“…Table provides a summary of the included studies [22,34––63], while Table provides a risk of bias summary of the included studies [22,34––63]. Seven studies were at high risk of bias , four were at low risk of bias , and the remaining 18 studies had an unclear risk of bias due to at least one of the four domains .…”

“…1 Table 2 provides a risk of bias summary of the included studies [22,34--63]. Seven studies were at high risk of bias [37,[41][42][43]47,48,51], four were at low risk of bias [22,53,55,58], and the remaining 18 studies had an unclear risk of bias due to at least one of the four domains [34][35][36][38][39][40][44][45][46]49,50,52,54,57,[60][61][62][63].…”

Qualitative and Quantitative Reporting of a Unique Biparametric MRI: Towards Biparametric MRI‐Based Nomograms for Prediction of Prostate Biopsy Outcome in Men With a Clinical Suspicion of Prostate Cancer (IMPROD and MULTI‐IMPROD Trials)

“…Widespread use of prostate MRI in men with clinical suspicion of PCa can create a major financial burned on healthcare systems around the world. Thus, the use of a more rapid and cost‐effective prostate MRI protocol without the use intravenous contrast agent is desired …”

Editorial for “Qualitative and Quantitative Reporting of a Unique Biparametric MRI: Towards Biparametric MRI‐Based Nomograms for Prediction of Prostate Biopsy Outcome in Men With a Clinical Suspicion of Prostate Cancer (IMPROD and MULTI‐IMPROD Trials)”

“…Furthermore, acquisition of a b = 2000 mm 2 /s may be a problem when calculating the ADC, since image noise at higher measured b‐values can lead to a calculation of falsely low ADC values, and therefore overestimation of the GS. On the other hand, numerous studies demonstrate the additional value of using high b‐values (>1500 s/mm 2 ) for the detection of sPCa . From the low b‐values that can be used for ADC calculation, however, high b‐values to increase sPCa detection can be extrapolated mathematically using different calculation models without additional measurement time, which could contribute to a more time‐ and cost‐effective protocol than that of the presented study.…”