Prostate Cancer: Comparison of Tumor Visibility on Trace Diffusion-Weighted Images and the Apparent Diffusion Coefficient Map

Rosenkrantz, Andrew B.; Kong, Xiangbin; Niver, Benjamin E.; Berkman, Douglas S.; Melamed, Jonathan; Babb, James S.; Taneja, Samir S.

doi:10.2214/ajr.10.4738

Cited by 30 publications

(10 citation statements)

References 39 publications

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“…In contrast, a recent study (5) reported that the diagnostic performance of DWI using a b value of 2000 s/mm 2 was superior to that of 1000 s/mm 2 ; however, that study used only index DWI for diagnostic criteria in cancer detection. Thus, their results are not surprising since the signal intensity of a normal prostate gland is very high and is often not suppressed using index DWI when using b values around 1000 s/mm 2 , due to T2-shine-through effects (1, 16). To overcome this persistent high signal within the prostate, several experts have used both index DWI and ADC maps in DWI interpretation to predict prostate cancer location (1, 16).…”

Section: Discussionmentioning

confidence: 95%

Diffusion-Weighted Magnetic Resonance Imaging for the Evaluation of Prostate Cancer: Optimal B Value at 3T

et al. 2013

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ObjectiveTo retrospectively determine the optimal b value of diffusion-weighted imaging (DWI) for predicting the presence of localized prostate cancer, and to evaluate the utility of DWI under different b values in differentiating between cancers and benign prostatic tissues.Materials and MethodsEighty patients with suspected prostate cancer underwent MRI including DWI at 3T, followed by radical prostatectomy. DWI was examined under different b values. Apparent diffusion coefficient (ADC) maps were generated by using b = 0, and other b values of 300, 700, 1000 or 2000 s/mm2. For predicting the presence of cancers, four different ADC maps were analyzed independently by two blinded readers. ADCs were measured in benign and malignant tissues.ResultsFor predicting the presence of 110 prostate cancers, the sensitivity and area under the curve (AUC) for an experienced reader was significantly greater at b = 1000 (85% and 0.91) than b = 300, 700 or 2000 s/mm2 (p < 0.01). For a less-experienced reader, the AUC was significantly greater at b = 700, 1000 or 2000 than b = 300 s/mm2 (p < 0.01). Mean ADCs of the cancers in sequence from b = 300 to 2000 s/mm2 were 1.33, 1.03, 0.88 and 0.68 × 10-3 mm2/s, which were significantly lower than those of benign tissues (p < 0.001).ConclusionThe optimal b value for 3T DWI for predicting the presence of prostate cancer may be 1000 s/mm2.

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Section: Discussionmentioning

confidence: 95%

Diffusion-Weighted Magnetic Resonance Imaging for the Evaluation of Prostate Cancer: Optimal B Value at 3T

et al. 2013

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“…Images with a b -value of 1000 s/mm 2 cannot suppress benign tissue in the PZ and sometimes obscure tumor lesions due to persistent T2-shine-through effects [19]. This aspect needs to be elicitated as the great spread of prostate cancers requires an increase in MRI examinations for diagnosis, local staging, lesions targeting for biopsy, or focal therapies, so that the interpretation of the mp-MRI must be easy in clinical practice, without the need of great experience.…”

Section: Discussionmentioning

confidence: 99%

DWI of Prostate Cancer: Optimalb-Value in Clinical Practice

et al. 2014

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Aim. To compare the diagnostic performance of diffusion weighted imaging (DWI) using b-values of 1000 s/mm2 and 2000 s/mm2 at 3 Tesla (T) for the evaluation of clinically significant prostate cancer. Matherials and Methods. Seventy-eight prostate cancer patients underwent a 3T MRI scan followed by radical prostatectomy. DWI was performed using b-values of 0, 1000, and 2000 s/mm2 and qualitatively analysed by two radiologists. ADC maps were obtained at b-values of 1000 and 2000 s/mm2 and quantitatively analyzed in consensus. Results. For diagnosis of 78 prostate cancers the accuracy of DWI for the young reader was significantly greater at b = 2000 s/mm2 for the peripheral zone (PZ) but not for the transitional zone (TZ). For the experienced reader, DWI did not show significant differences in accuracy between b-values of 1000 and 2000 s/mm2. The quantitative analysis in the PZ and TZ was substantially superimposable between the two b-values, albeit with a higher accuracy with a b-value of 2000 s/mm2. Conclusions. With a b-value of 2000 s/mm2 at 3T both readers differentiated clinical significant cancer from benign tissue; higher b-values can be helpful for the less experienced readers.

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“…Advances in prostate MRI has aided in detection and characterisation of prostate cancer using a multiparametric approach [40]. Prostate cancer in the peripheral zone typically demonstrate low T2 signal with corresponding low signal on ADC [41]. Additional features include extension of abnormal low signal tissue beyond the prostatic "capsule" (ie: extracapsular extension) and invasion of the seminal vesicles.…”

Section: Prostate Cancermentioning

confidence: 99%

Clinical applications of 3D T2-weighted MRI in pelvic imaging

et al. 2014

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Prostate Cancer: Comparison of Tumor Visibility on Trace Diffusion-Weighted Images and the Apparent Diffusion Coefficient Map

Abstract: Given a greater proportion of tumors visible on the ADC map than trace DWI and greater contrast relative to benign PZ on the ADC map, we suggest that, when performing DWI of the prostate, careful attention be given to the ADC map for tumor identification.

Cited by 30 publications

References 39 publications

Diffusion-Weighted Magnetic Resonance Imaging for the Evaluation of Prostate Cancer: Optimal B Value at 3T

Diffusion-Weighted Magnetic Resonance Imaging for the Evaluation of Prostate Cancer: Optimal B Value at 3T

DWI of Prostate Cancer: Optimalb-Value in Clinical Practice

Clinical applications of 3D T2-weighted MRI in pelvic imaging

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