Prostate Cancer Brain Metastases: A Single-Institution Experience

Bhambhvani, Hriday P.; Greenberg, Daniel S.; Srinivas, Sandy; Gephart, Melanie Hayden

doi:10.1016/j.wneu.2020.02.152

Cited by 29 publications

(65 citation statements)

References 24 publications

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“…Renal cell and prostate carcinoma metastasize to the brain in 2–16% and less than 1% of cases, respectively. 37 , 38 Predictive factors for these cancers to metastasize to the brain are less well studied, though in prostate carcinomas it has been seen that there may be differences in the likelihood of brain metastasis based on subtype. 25 Tremont-Lukats et al found no significant tendencies for brain metastases from prostate carcinoma to travel to a particular location overall or by histologic subtype in a study of 103 patients.…”

Section: Resultsmentioning

confidence: 99%

Anatomical and topographical variations in the distribution of brain metastases based on primary cancer origin and molecular subtypes: a systematic review

Cardinal

Pangal

Strickland

et al. 2021

Neuro-Oncology Advances

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Background While it has been suspected that different primary cancers have varying predilections for metastasis in certain brain regions, recent advances in neuro-imaging and spatial modeling analytics have facilitated further exploration into this field. Methods A systematic electronic database search for studies analyzing the distribution of brain metastases (BM) from any primary systematic cancer published January 1990-July 2020 was conducted using PRISMA guidelines. Results Two authors independently reviewed 1,957 abstracts, 46 of which underwent full-text analysis. A third author arbitrated both lists; 13 studies met inclusion/exclusion criteria. All were retrospective single- or multi-institution database reviews analyzing over 8,227 BMs from 2,599 patients with breast (8 studies), lung (7 studies), melanoma (5 studies), gastrointestinal (4 studies), renal (3 studies), and prostate (1 study) cancers. Breast, lung, and colorectal tended to metastasize to more posterior/caudal topographic and vascular neuroanatomical regions, particularly the cerebellum, with notable differences based on subtype and receptor expression. HER-2 positive breast cancers were less likely to arise in the frontal lobes or subcortical region, while ER-positive and PR-positive breast metastases were less likely to arise in the occipital lobe or cerebellum. BM from lung adenocarcinoma tended to arise in the frontal lobes, and squamous cell carcinoma in the cerebellum. Melanoma metastasized more to the frontal and temporal lobes. Conclusion The observed topographical distribution of BM likely develops based on primary cancer type, molecular subtype, and genetic profile. Further studies analyzing this association and relationships to vascular distribution are merited to potentially improve patient treatment and outcomes.

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Section: Resultsmentioning

confidence: 99%

Anatomical and topographical variations in the distribution of brain metastases based on primary cancer origin and molecular subtypes: a systematic review

Cardinal

Pangal

Strickland

et al. 2021

Neuro-Oncology Advances

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show abstract

“…In our patient, a possibility of a relapse of his prostate tumor had to be considered. However, the presence of brain metastases is an anecdotal phenomenon in patients with prostate cancer [ 5 ], so an extensive work-up study was needed in order to rule out a different primary tumor and establish the disease burden.…”

Section: Discussionmentioning

confidence: 99%

Proptosis and a Dermal Lesion as the Presenting Sign of Lung Adenocarcinoma

Plana

Puzo

Santos-Alarcón

et al. 2021

Case Rep Ophthalmol

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The purpose is to describe a clinical case of orbital metastases as the presentation sign of the primary tumor, and the importance of a multidisciplinary diagnosis. A 70-year-old man attended the Ophthalmology Department referring ocular pain. Mild proptosis and a dermal lesion in the neck were noticed. Biopsy of the dermal lesion and systemic work-up were compatible with lung adenocarcinoma with metastatic dissemination. After one cycle of palliative chemotherapy, patient’s medical condition worsened, and he eventually died. Although rare, orbital symptoms can be the initial clinical presentation preceding the diagnosis of the primary silent lung neoplasm. Ophthalmologist has an important role in diagnoses of metastatic orbital cancer. Involvement of the multidisciplinary team is important for diagnosis and treatment.

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“…25,26 As mentioned above, brain metastases from prostate cancer are rare, and typically occurred in the more advanced stages of the disease, in the context of a disseminated systemic symptomatic disease. 3,4,27 Early diagnosis of visceral disease -and particularly brain parenchymal involvement -is crucial, possibly positively impacting on patient's management and prognosis. 28 MRI is the modality of choice for the detection of brain metastases.…”

Section: Dovepressmentioning

confidence: 99%