Prostate Basal Cell Carcinoma: A Case Report

Abstract

Prostate basal cell carcinoma (PBCC) accounts for 0.01% of all prostate cancers. A 68-year-old man complained of dysuria for 5 years on his initial visit. His PSA level was 3.87 ng/mL. Due to a diagnosis of benign prostate hyperplasia, he underwent transurethral resection of the prostate. A pathological examination revealed that basal cell-like atypical cells made alveolar with palisadal layout. Immunohistochemical analysis showed positive 34β12, P63, and Ki-67. Based on these findings, PBCC was diagnosed. Then, we performed radical prostatectomy. He was free from recurrence 22 months after the operation. We herein report an extremely rare case of PBCC.

Primary basal cell carcinoma of the prostate with concurrent adenocarcinoma

“…The histology of healthy prostate glandular tissue comprises acini and ducts lined by secretory epithelium. Beneath the secretory lining is a layer of basal cells as well as interspersed endocrine‐paracrine cells . Basal cell carcinoma of the prostate was first reported in 1974, and can be classified as adenoid cystic or basaloid cell origin .…”

“…Histologically, infiltrating basaloid cells form dilated acinar cribriform spaces with admixed glandular or trabecular material . Tumors predominate in the transitional zone of the prostate, leading to early symptomatic bladder outlet obstruction and an enlarged and indurated gland on digital rectal examination . Both subtypes of PBCC have been found with co‐existent acinar adenocarcinoma .…”

“…yielded 98 cases of PBCC upon searching the PubMed electronic database. A wider search of the literature by our group revealed a total of 139 cases, of which 102 cases were published clinical reviews . When summarizing these cases, the mean age at PBCC diagnosis was 67.9 ± 11.6, and the mean period of follow‐up was 37.7 ± 37.3 months.…”

“…Beneath the secretory lining is a layer of basal cells as well as interspersed endocrine-paracrine cells. 1 Basal cell carcinoma of the prostate was first reported in 1974, and can be classified as adenoid cystic or basaloid cell origin. 2 Histologically, infiltrating basaloid cells form dilated acinar cribriform spaces with admixed glandular or trabecular material.…”

“…2,3 Tumors predominate in the transitional zone of the prostate, leading to early symptomatic bladder outlet obstruction and an enlarged and indurated gland on digital rectal examination. 1 Both subtypes of PBCC have been found with co-existent acinar adenocarcinoma. 4 Serum PSA is usually low or normal, however, it can be elevated in patients who also have acinar adenocarcinoma.…”