Prostate arterial chemoembolization for treatment of refractory hematuria and urinary retention in patients with localized advanced prostate cancer

Wang, Mao Qiang; Zhang, Jinlong; Duan, Feng; Yuan, Bing; Xin, Hainan; Fu, Jinxin; Ye, Hui Yi; Yu, Hong Kai; Feng, Dan; Cheng, Kai; Zhang, Xiu Jun

doi:10.1038/s41391-022-00516-7

Cited by 4 publications

(6 citation statements)

References 27 publications

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“…In a recent study, Wang et al 20 found that all 32 patients experienced spontaneous bleeding control within 5 days of PAE, and that during the average 30-month follow-up, 17 patients experienced spontaneous urination again. Men diagnosed with prostate cancer often exhibit advanced age, and they commonly experience a higher incidence of detrusor underactivity due to prolonged reliance on pre-procedural catheters.…”

Section: Discussionmentioning

confidence: 97%

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The Efficacy of Prostatic Artery Embolization (PAE) as Palliative Therapy in Prostate Cancer

Yunita Lestari Indrianto,

Evan Nugroho,

Bartolomeus Alvin Tjandra

et al. 2024

World J. Adv. Res. Rev.

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Introduction: Prostate cancer, the primary contributor to cancer-related fatalities in Western countries, predominantly impacts individuals between the ages of 45 and 60. The World Health Organization (WHO) has documented 1,414,259 new cases worldwide. Diagnosis methods include prostate biopsy, PSA testing, and MRI, with risk factors such as age, weight, race, and family history contributing to the varied epidemiology of the disease. Treatment alternatives such as surgery and radiation therapy come with notable side effects, prompting ongoing research into alternatives like prostate artery embolization (PAE) for benign prostatic obstruction. However, the role of PAE in patients with prostate cancer remains uncertain. Aim: The purpose of this systematic review is to determine the efficacy of Prostatic Artery Embolization as one of the palliative management strategies for clinical outcomes in prostate cancer. Method: We searched for English-language full-text literature from Pubmed, Cochrane, Wiley Library, Proquest, SpringerLink, and ScienceDirect databases from January 2013 to Desember 2023. Based on the 1442 journals identified in this study, the number of evaluated articles is 6. Results: In six studies, PAE induces tissue ischemia through femoral artery embolization, offering promise for localized prostate cancer treatment. Administered under local anesthesia, PAE has shorter hospital stays and is well-tolerated compared to TURP. After PAE treatment, significant IPSS reduction occurred, with improved outcomes reported at 1 and 6 months. Histopathology showed necrotic zones, but viable cancer cells persisted. PAE is a valuable adjunctive therapy for reducing organ-at-risk doses in exclusive prostate radiation therapy. Conclusion: PAE is a minimally invasive treatment for LUTS related to BPH and its potential in managing PCa. PAE, utilizing femoral artery occlusion, shows significant short and medium-term reductions in IPSS. While there's notable success in PCa management and reduced radiation doses, further research is essential for a comprehensive understanding of PAE's efficacy in localized PCa treatment.

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Section: Discussionmentioning

confidence: 97%

“…Consensus was used to settle disagreements. Six reviewed studies [15][16][17][18][19][20] were found to have achieved seven or more stars using the modified NOS star system, which has a range of 0-9 stars. As a result, these studies were classified as good quality studies.…”

Section: Quality Assessment and Risk Of Bias Assessmentmentioning

confidence: 99%

The Efficacy of Prostatic Artery Embolization (PAE) as Palliative Therapy in Prostate Cancer

Yunita Lestari Indrianto,

Evan Nugroho,

Bartolomeus Alvin Tjandra

et al. 2024

World J. Adv. Res. Rev.

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“…16 17 18 Additionally, TACE has also been described in primary lung, gynecologic, prostate, and renal cell malignancies, bone/soft tissue sarcoma, and retinoblastomas. 19 20 21 22 23 24…”

Section: Chemoembolization In Interventional Radiologymentioning

confidence: 99%

“…[16][17][18] Additionally, TACE has also been described in primary lung, gynecologic, prostate, and renal cell malignancies, bone/soft tissue sarcoma, and retinoblastomas. [19][20][21][22][23][24] TACE in general can be categorized as conventional (cTACE) using lipiodol as a vehicle for chemotherapy or drug-eluting bead TACE (DEB-TACE) with microspheres adsorbed with drugs. [1][2][3] Anthracyclines, for instance doxorubicin, are the most used chemotherapeutic agent in TACE of hepatocellular carcinoma and are derived from Streptomyces spp.…”

Section: Chemoembolization In Interventional Radiologymentioning

confidence: 99%

Oncopharmacology in Interventional Radiology

Raja

Madoff

2022

Semin intervent Radiol

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The broad scope of malignancies treated in interventional oncology is mirrored by the breadth of oncotherapeutics, drugs used to treat cancer. Many of these treatments are administered endovascularly, though a group of therapies can be delivered percutaneously. Perhaps the best taxonomy of oncotherapeutics is based on their biological inactivity or activity and the mechanism by which they interact with treated and targeted tissues. As the fields of interventional oncology and oncotherapeutics continue to grow and expand, this framework may provide a more organized approach in helping distinguish and select the best therapy for patients.

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“…While bland embolization has been insufficient oncologically, other approaches have been explored. Chemoembolization with several agents has been explored; however, short-term oncologic response ranges from 60-70%, well below acceptable PCa oncologic outcomes seen with standard of care prostatectomy, radiotherapy (RT), and/or androgen deprivation [7][8][9]. However, all studies confirm that the embolotherapy approach is safe in these patients.…”

mentioning

confidence: 99%

What Role Does PAE Play in the Management of Prostate Cancer?

Mouli

2024

Cardiovasc Intervent Radiol

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Prostate arterial chemoembolization for treatment of refractory hematuria and urinary retention in patients with localized advanced prostate cancer

Cited by 4 publications

References 27 publications

The Efficacy of Prostatic Artery Embolization (PAE) as Palliative Therapy in Prostate Cancer

The Efficacy of Prostatic Artery Embolization (PAE) as Palliative Therapy in Prostate Cancer

Oncopharmacology in Interventional Radiology

What Role Does PAE Play in the Management of Prostate Cancer?

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