Prostasomes as a source of diagnostic biomarkers for prostate cancer

Zijlstra, C.; Stoorvogel, Willem

doi:10.1172/jci81128

Cited by 57 publications

(51 citation statements)

References 121 publications

(143 reference statements)

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“…Prostate cancer, one of the most frequently diagnosed cancers (56,57), is an example in which diagnostic biomarkers associated with prostatederived EVs, termed "prostasomes," could have a huge impact, since this could allow an unprecedented accurate determination of aggressive versus nonaggressive disease forms. In this Review series, Zijlstra and Stoorvogel propose that screening of proteins and RNA in immunoisolated prostasomes may serve to locate biomarkers for prostate cancer diagnosis, differentiation, prognosis, and epidemiology (58).…”

Section: Clinical Applications For Evsmentioning

confidence: 99%

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

Pitt¹,

Kroemer²,

Zitvogel³

2016

Journal of Clinical Investigation

396

311

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Intercellular signaling via extracellular vesicles (EVs) is an underappreciated modality of cell-cell crosstalk that enables cells to convey packages of complex instructions to specific recipient cells. EVs transmit these instructions through their cargoes of multiple proteins, nucleic acids, and specialized lipids, which are derived from their cells of origin and allow for combinatorial effects upon recipient cells. This Review series brings together the recent progress in our understanding of EV signaling in physiological and pathophysiological conditions, highlighting how certain EVs, particularly exosomes, can promote or regulate infections, host immune responses, development, and various diseases -notably cancer. Given the diverse nature of EVs and their abilities to profoundly modulate host cells, this series puts particular emphasis on the clinical applications of EVs as therapeutics and as diagnostic biomarkers.

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Section: Clinical Applications For Evsmentioning

confidence: 99%

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

Pitt¹,

Kroemer²,

Zitvogel³

2016

Journal of Clinical Investigation

396

311

View full text Add to dashboard Cite

show abstract

“…The content and number of EVs can be altered under different conditions, such as stress or immune response. As EVs contain a portion of the material from the parent cell, they have recently become a potentially rich source of clinically relevant non‐invasive diagnostic markers for cancer in biofluids, such as blood, urine, cerebral spinal fluid, and milk (Zijlstra and Stoorvogel, 2016; Nawaz et al, 2017). EVs are quite stable and are resistant to proteolytic enzymes and nuclease activities.…”

Section: Role Of Evs In Hematopoiesis/hematological Malignanciesmentioning

confidence: 99%

Mesenchymal stromal cell‐derived extracellular vesicles as cell‐free biologics for the ex vivo expansion of hematopoietic stem cells

Budgude

Kale

Vaidya

2020

Cell Biology International

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Hematopoietic stem cell transplantation (HSCT) is the ultimate choice of treatment for patients with hematological diseases and cancer. The success of HSCT is critically dependent on the number and engraftment efficiency of the transplanted donor hematopoietic stem cells (HSCs). Various studies show that bone marrow-derived mesenchymal stromal cells (MSCs) support hematopoiesis and also promote ex vivo expansion of HSCs. MSCs exert their therapeutic effect through paracrine activity, partially mediated through extracellular vesicles (EVs). Although the physiological function of EVs is not fully understood, inspiring findings indicate that MSC-derived EVs can reiterate the hematopoiesis, supporting the ability of MSCs by transferring their cargo containing proteins, lipids, and nucleic acids to the HSCs. The activation state of the MSCs or the signaling mechanism that prevails in them also defines the composition of their EVs, thereby influencing the fate of HSCs. Modulating or preconditioning MSCs to achieve a specific composition of the EV cargo for the ex vivo expansion of HSCs is, therefore, a promising strategy that can overcome several challenges associated with the use of naïve/unprimed MSCs. This review aims to speculate upon the potential role of preconditioned/primed MSC-derived EVs as "cell-free biologics," as a novel strategy for expanding HSCs in vitro.

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“…Prostasomes also protect spermatozoa from infection and phagocytosis by female immune cells, thereby contributing to human reproduction . Furthermore, PCa cells have been shown to release prostasomes …”

Section: Biogenesis Of Evsmentioning

confidence: 99%

Extracellular vesicles: Toward a clinical application in urological cancer treatment

Urabe

Kosaka²,

Kimura

et al. 2018

Int J of Urology

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Extracellular vesicles are nanometer-sized lipid membranous vesicles that are released from almost all types of cells into the extracellular space. Extracellular vesicles have gained considerable attention in the past decade, and emerging evidence suggests that they play novel roles in mediating cancer biology. Extracellular vesicles contain pathogenic components, such as proteins, DNA fragments, messenger ribonucleic acids, non-coding ribonucleic acids and lipids, all of which mediate paracrine signaling in the tumor microenvironment. Extracellular vesicles impact the multistep process of cancer progression through modulation of the immune system, angiogenesis and pre-metastatic niche formation through transfer of their contents. Therefore, a better understanding of their roles in urological cancers will provide opportunities for novel therapeutic strategies. In addition, the contents of extracellular vesicles hold promise for the discovery of liquid-based biomarkers for prostate, kidney and bladder cancers. Here, we summarize the current research regarding extracellular vesicles in urological cancer and discuss potential clinical applications for extracellular vesicles in urological cancer.

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Prostasomes as a source of diagnostic biomarkers for prostate cancer

Cited by 57 publications

References 121 publications

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

Mesenchymal stromal cell‐derived extracellular vesicles as cell‐free biologics for the ex vivo expansion of hematopoietic stem cells

Extracellular vesicles: Toward a clinical application in urological cancer treatment

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