Prostanoids. Part LXIX. Synthesis of (±)-11,15-dideoxy-16-methyl-16-hydroxyprostaglandin E1 ethyl ester

Synthesis of ethyl (±)-(13,15-dideoxy)-16-methyl-9-oxoprosta-13(E,Z),15(E)-dienoate

“…Several years ago we suggested a replacement of the synthetically diffi cultly available and labile compound I by its "structurally-simplifi ed version" of the like topology, 11-deoxyderivative II [3]. Despite the lack of the pharmacologically important 11-hydroxy function, compound II in the signifi cant biotests (antiulcer and contractile action on the plain muscles of uterus) proved to be more active than misoprostol (I).…”