Prostanoids and Related Compounds. VI. Synthesis of Isoindolinone Derivatives Possessing Inhibitory Activity for Thromboxane A2 Analog (U-46619)-Induced Vasoconstriction.

Entonalactams A–C: Isoindolinone derivatives from an Australian rainforest fungus belonging to the genus Entonaema

“…The isoindolinone motif is not only a core structure in natural products such as daldinan A from the saprotrophic fungus Daldinia concentrica (Lee et al, 2012), stachybotrin C from the culture broth of Stachybotrys parvispora (Nozawa et al, 1997a;Nozawa et al, 1997b), lennoxamine from Berberis species (Fuchs and Funk, 2001), cichorine from Aspergillus silvaticus (Kawahara et al, 1988), fumaramidine from Fumaria parviflora (Hussain et al, 1981), and pestalachloride A from co-fermentation of a marine fungus and a marine bacterium (Li et al, 2008), but is also found in a number of pharmacologically relevant synthetic molecules such as (S)-PD 172938 (Belliotti et al, 1998), and ASK 186 (Kato et al, 1993;Lamblin et al, 2006).…”

Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors

“…A standard procedure was used to transform final compounds into their hydrochloride salts. The following intermediates have been prepared following literature methods: 5-methoxy-2-tetralone (Cornforth & Robinson 1949), 3-(1-piperazinyl)-1,2-benzisoxazole (Yevich et al 1986), 1-(2-chloroethyl)-3-methoxybenzene (Kato et al 1993), 1-(2-chloroethyl)-2-methoxybenzene (Kato et al 1993), 1-(2-chloroethyl)-2,6-dimethoxybenzene (Boltze & Dell 1967), 2,3,4-trimethoxyphenylacetic acid (Arndts et al 1994). All reactions were carried out under an atmosphere of nitrogen.…”

A Facile Direct Synthesis of 3‐Methyleneisoindolin‐1‐ones by Annulation of Methyl 2‐Acylbenzoates with Amines

“…For example, AL‐5 ( I ) and AL‐12B ( II ) exhibit local anesthetic activity superior to that of common local anesthetics . AKS 186 ( III ) is a known vasoconstriction inhibitor ,. Compound IV is a good bioactive indicator receptor antagonist.…”

“…Compound IV is a good bioactive indicator receptor antagonist. 1d Compound V exhibits sedative activity . Fumaridine ( VI ) was extracted from vegetable sources .…”