“…In contrast, a wide array of growth factors, cytokines, and other endocrine products, including epidermal growth factor, transforming growth factor-b, Wnt-10b, PREF-1, resistin, and the pro-inflammatory cytokines tumor necrosis factor-a, interleukin-6 and interleukin-1, have all been shown to potently inhibit adipogenesis [MacDougald and Mandrup, 2002]. Another class of products known to influence adipocyte differentiation is the prostaglandins [Serrero et al, 1992;Lepak and Serrero, 1993;Forman et al, 1995;Casimir et al, 1996;Reginato et al, 1998;Aubert et al, 2000]. The prostaglandins are a diverse class of structurally distinct metabolic products of arachidonic acid that are generated via the concerted actions of cyclooxygenases and other subsequent synthetic enzymes [Vane et al, 1998].…”