Prostaglandins in the human fetal circulation in mid-trimester and term pregnancy

Mackenzie, I. Z.; MacLean, David; Mitchell, Murray D.

doi:10.1016/0090-6980(80)90105-7

Cited by 34 publications

(3 citation statements)

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“…Mean circulating levels of plasma 6-0x0-PGFla expressed as immunochemical equivalents from 12 patients sampled serially during The decrease in circulating maternal 6-0x0-PGF,, levels during the second half of pregnancy is similar to declining levels reported in the fetal circulation (MacKenzie et al, 1980) and to the fall in activity of the putative plasma prostacyclin stimulating factor found during the same period (Remuzzi et al, 1981).…”

Section: Resultssupporting

confidence: 57%

MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F_1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

Bolton¹,

Jogee²,

Myatt³

et al. 1981

BJOG

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Section: Resultssupporting

confidence: 57%

MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F_1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

Bolton¹,

Jogee²,

Myatt³

et al. 1981

BJOG

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“…8 In vitro, human umbilical vessel preparations demonstrate dosedependent vasoconstriction. 9 In previous Doppler studies, there is no change in the flow index of the fetal umbilical artery after vaginal or extra-amniotic administration of prostaglandin Eg. 10 -11 In accordance with these studies, the umbilical artery PI remained unchanged during followup.…”

Section: Discussionmentioning

confidence: 88%

Vaginal and Intracervical Prostaglandin E₂For Cervical Ripening: A Doppler Study of Hemodynamic Effects

Polvi¹,

Pirhonen²,

Erkkola³

1994

Amer J Perinatol

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The hemodynamic effects of vaginally and intracervically administered prostaglandin E2 gel were evaluated by pulsed wave color Doppler ultrasound. Twenty term pregnant mothers were recruited. Mothers were randomized to receive either vaginal or intracervical prostaglandin E2 gel. The hemodynamics was assessed by repeated color Doppler velocimetry of the uterine artery and fetal umbilical and middle cerebral arteries; analysis of variance was used to test statistical significance. In the uterine artery a statistically significant rise (P < or = 0.001) of the pulsatility index (PI) was observed. A slightly higher rise of the PI was observed after intracervical administration, but the difference between the groups was not statistically significant (P = 0.4). The fetal PI remained unchanged both in the umbilical and cerebral vessels throughout the study. The rise in the uterine artery PI is probably caused by an increase in the uterine tone as prostaglandins of the E series usually cause vasodilation. No detectable fetal effects were evident.

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“…Weitere Arbeitsgruppen befaßten sich mit Untersuchungen an schwangeren Hunden (120,122 (63,86,95,113). Die PGIZ-Produktion ist im Fetus wesentlich höher als bei der Mutter (63,95). Die höheren fetalen PGI,-Spiegel stehen dabei möglicherweise mit einer höheren Plasma-Renin-Aktivität in ursächlichem Zusammenhang (79).…”

Section: Experimente Bei Hundenunclassified

Über die Bedeutung der Prostaglandine und anderer Eicosanoide für Physiologie und Pathophysiologie der Schwangerschaft

Th¹

1986

Geburtsh Frauenheilk

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Numerous investigations in animals and humans on the role of eicosanoids in pregnancy yielded the following results. During normal pregnancy, there is an increased production of eicosanoids with a vasodilatory action, prostaglandin E2 (PGE2) and prostacyclin (PGI2), especially in the uteroplacental and renal regions. This additional production contributes to a reduction in peripheral resistance so that the increase of blood volume which is specific for pregnancy can occur without increase in blood pressure. The fact that eicosanoids participate in this mechanism is shown by administration of prostaglandin synthesis inhibitors, thus producing a rise in blood pressure. In the autoregulation of the vessels, interactions between renin angiotensin and PGE2 and PGI2 are thought to play an important role also in pregnancy. In support of this concept it has been shown that the pregnancy-specific reduction in vasoconstrictor action of angiotensin, is abolished when prostaglandin synthesis inhibitors are given. It is assumed that PGE2/PGI2 production and the renin angiotensin production influence each other physiologically. Another important factor in the control of the haemodynamics and blood coagulation is represented by the prostacyclin-thromboxane system. In normal pregnancy there should be a production equilibrium between the two antagonistic eicosanoids. In preeclampsia this equilibrium, which is particularly marked in the placenta and region of the foetal vessels, is disturbed with decreasing PGI2. The main symptoms of preeclampsia--increase in blood pressure, coagulation disturbances and diminished placental circulation--can be derived from this. In diabetes and foetal growth retardation, both of which predispose to preeclampsia, similar changes in eicosanoid production have been observed. Hence, in case of preeclampsia with disturbed eicosanoid production the administration of prostaglandin synthesis inhibitors such as peripherally acting analgesics and corticoids is contraindicated. Approaches to a rational therapy such as administration of thromboxane synthesis inhibitors, a diet with prostaglandin precursors and infusions of PGI2 appear promising according to preliminary results. Further advances may be expected after the function of eicosanoids of the lipoxygenase paths in preeclampsia has been elucidated.

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Prostaglandins in the human fetal circulation in mid-trimester and term pregnancy

Cited by 34 publications

References 5 publications

MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F_1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F_1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

Vaginal and Intracervical Prostaglandin E₂For Cervical Ripening: A Doppler Study of Hemodynamic Effects

Über die Bedeutung der Prostaglandine und anderer Eicosanoide für Physiologie und Pathophysiologie der Schwangerschaft

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Prostaglandins in the human fetal circulation in mid-trimester and term pregnancy

Cited by 34 publications

References 5 publications

MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

Vaginal and Intracervical Prostaglandin E2For Cervical Ripening: A Doppler Study of Hemodynamic Effects

Über die Bedeutung der Prostaglandine und anderer Eicosanoide für Physiologie und Pathophysiologie der Schwangerschaft

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Product

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MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F_1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

MATERNAL PLASMA 6‐OXO‐PROSTAGLANDIN F_1α LEVELS THROUGHOUT PREGNANCY: A LONGITUDINAL STUDY

Vaginal and Intracervical Prostaglandin E₂For Cervical Ripening: A Doppler Study of Hemodynamic Effects