Prostaglandins in Pyometrial Fluid From the Cow, Bitch and Ferret

Abstract

Pyometra is a disorder of the uterus usually associated with bacterial infection plus obstruction. Large quantities of fluid often collect in the uterus during this condition. Pyometrial fluid obtained from three species was found to contain prostaglandin F2α, usually in large quantities. Prostaglandin E2 was present in smaller quantities in five of the six samples. These findings are discussed in relation to the known occurrence of prostaglandins in inflammatory fluid, and to the problem of infertility.

Measurement of C‐reactive protein and Prostaglandin F2α Metabolite Concentrations in Differentiation of Canine Pyometra and Cystic Endometrial Hyperplasia/Mucometra

“…In pyometra, bacterial infection and subsequent endotoxin release cause the endometrium to produce prostaglandins which is reflected by an increase in PGFM concentrations (Heap and Poyser ; Vandeplassche et al. ; Hagman ; Hagman et al.…”

“…In pyometra, bacterial infection and subsequent endotoxin release cause the endometrium to produce prostaglandins which is reflected by an increase in PGFM concentrations (Heap and Poyser 1975;Vandeplassche et al 1991;Hagman 2004;Hagman et al (2006a,b)). Hagman et al (2006a,b) found significantly higher mean serum PGFM concentrations in dogs with pyometra (6278 pmol/l) compared to CEH/ mucometra (415 pmol/l) and control (86 pmol/l) dogs.…”

“…Uterine tissue synthesizes and releases prostaglandins, mainly prostaglandin F 2a (PGF 2a ) during inflammation (Heap and Poyser 1975). The presence of PGF 2a can be detected by measuring its circulating metabolite 15-keto-(13,14)-dihydro-PGF 2a (PGFM) (Granstrom and Kindahl 1982;Hagman et al (2006a,b) Hagman et al 2009).…”

Concentrations of uterine luminal prostaglandins in mares with acute and persistent endometritis

“…A more recent study has shown prematurely elevated concentrations of PGFM in plasma which have been associated with luteolysis in two mares with endometritis (Neely et a1 1979) and it was hypothesised that uterine infection led to increased synthesis of PGFZq by the inflammatory process and/or the presence of bacterial toxins. Pyometrial fluid from bitches, cows and ferrets has been shown to contain high concentrations of PGF, and PGE (Heap and Poyser 1975) and in cattle the concentrations of PGF in pyometrial fluid were significantly correlated with plasma concentrations of PGFM (Nkuuhe 1 982).…”

Aplicabilidad de la ultrasonografía Doppler y electrocardiografía en la evaluación de parámetros cardiovasculares en condiciones fisiológicas y patológicas uterinas en los caninos domésticos

“…In women, uterine inflammation associated with an infectious process may lead to a diminution of RI values of uterine arteries [12]. Furthermore, a previous study in bitches with pyometra reported an increase in the intrauterine concentration of prostaglandin E, which may also lead to an increase in uterine perfusion [25,26]. In addition to prostaglandins, nitric oxide, a potent vasodilator, is also released locally in several mammalian species during endometrial inflammation [27,28].…”