Prostaglandins F<sub>2</sub>α and E<sub>2</sub> in rat placenta and fetal membrane: a comprehensive immunohistochemistry of their synthetic enzymes and <i>in vivo</i> tissue levels during normal pregnancy
Abstract:We determined a comprehensive immunohistochemistry of putative isoforms of enzymes for prostaglandin (PG) F2 and PGE2 biosynthesis and these PGs levels in placenta and fetal membrane of normal pregnant rats in vivo. Placenta and fetal membrane showed positive immunoreactions for phospholipase A2 group 4A, but not group 2A, and cyclooxygenase (COX)-1 rather than COX-2. They showed positive immunoreactions for at least one isoform of each of PGF synthase and PGE synthase with tissue-dependent variations. PGF2 … Show more
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