Prostaglandins F in Uterine Venous Plasma, Ovarian Arterial and Venous Plasma and in Ovarian and Luteal Tissue of Pregnant and Nonpregnant Ewes

Pexton, J.E.; Weems, C.W.; Inskeep, E. K.

doi:10.2527/jas1975.411154x

Cited by 60 publications

(10 citation statements)

References 17 publications

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“…Thorburn, Cox, Currie, Restall & Schneider (1973) have shown that in early pregnancy surges in utero-ovarian venous PGF levels were either absent on Days 12-16 or were very much reduced relative to the levels observed at similar times in the non-pregnant cycle. These findings are not supported by other workers who obtained no significant reduction in PGF levels in uterine venous blood or endometrium when pregnant and non-pregnant animals were compared (WUson et al, 1972;Pexton, Weems & Inskeep, 1975).…”

Section: Introductioncontrasting

confidence: 79%

Hormone involvement in the establishment of pregnancy

Sauer¹

1979

Reproduction

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Section: Introductioncontrasting

confidence: 79%

Hormone involvement in the establishment of pregnancy

Sauer¹

1979

Reproduction

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“…24 However, during ruminant preestrus/estrus, the concentration of PGF 2␣ in the uterine venous blood is substantial, being about 1-3 ng/mL in the cow 23 and about 6-7 ng/mL in the ewe. 30,31 Because LH does increase cyclooxygenase and its products in the uterine vein during preestrus/estrus, some of the prostaglandin measured in the uterine venous blood at this time could well be the result of prostanoid production in the vein itself.…”

Section: Physiological Significance Of Lh Stimulation Of Uterine Veinmentioning

confidence: 99%

Functional Importance of Bovine Myometrial and Vascular LH Receptors and Cervical FSH Receptors

Shemesh¹,

Mizrachi²,

Gurevich³

et al. 2001

Semin Reprod Med

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Bovine myometrium and cervix contain luteinizing hormone/human chorionic gonadotropin (LH/hCG) binding sites, LH receptor (LH-R) messenger RNA (mRNA), and LH-R protein. Expression of LH-R is dependent on the stage of the cycle. LH-R expression is high during the luteal phase but weak during the follicular phase. In both myometrium and cervix, LH activates both the adenylate cyclase and phospholipase C pathways, and the effect of LH on both pathways at each stage of the cycle is correlated with the amount of LH-R present in the tissue. Because activation of cyclic AMP (cAMP) is associated with myometrial quiescence, we suggest that LH activation of uterine cAMP could serve to keep the uterus quiescent during the luteal phase. On the other hand, in the uterine vein LH-R mRNA and LH-R are maximal during preestrus/estrus as opposed to the luteal phase. In the uterine vein, LH increases the expression of cyclooxygenase and production of both prostaglandin E2 (PGE2) and PGF2 alpha. Because PGF2 alpha is the physiological luteolytic signal in the cow, we suggest that this increase in prostaglandin production by the uterine vein is part of the physiological events leading to luteolysis. In addition to uterine LH-R, the bovine cervix at preestrus/estrus has high levels of follicle-stimulating hormone receptor (FSH-R) and its corresponding mRNA. As with LH-R, activation of FSH-R by FSH is associated with activation of a G protein-coupled receptor family that mediates the cAMP and inositol phosphate signaling pathways. Activation of these signaling pathways is associated with an increase in the expression of cyclooxygenase and production of PGE2. Because expression of the FSH receptor was maximal at the time of the FSH peak in the blood, we suggest a physiological role for FSH in the cervix relaxation and opening at estrus.

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“…At both times the increase in PGF production is associated with changes in the secretion of pro¬ gesterone and oestradiol, and various investigators have examined the effects of exogenous steroids on PGF synthesis and release (Caldwell, Tillson, Brock & Speroff, 1972; Wilson, Butcher, Cenedella & Inskeep, 1972;Barcikowski, Carlson, Wilson & McCracken, 1974;Ford, Weems, Pitts, Pexton, Butcher & Inskeep, 1975;Pexton, Weems & Inskeep, 1975a,¿>). In most of these studies, however, the animals were anaesthetized in order to collect a single sample of blood by venepuncture from the utero-ovarian vein, necessitating handling of the uterus and the associated vein, or peripheral blood samples were taken.…”

Section: Introductionmentioning

confidence: 99%

EFFECTS OF EXOGENOUS PROGESTERONE AND OESTRADIOL ON PROSTAGLANDIN F AND 13,14-Dihydro-15-Oxo PROSTAGLANDIN F2α CONCENTRATIONS IN UTERI AND PLASMA OF OVARIECTOMIZED EWES

Louis¹,

Parry²,

Robinson³

et al. 1977

Journal of Endocrinology

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The control of prostaglandin (PG) production by steroid hormones has been investigated in non-pregnant bilaterally ovariectomized sheep, prepared with indwelling utero-ovarian venous catheters and treated with physiological amounts of oestradiol and progesterone. Oestradiol treatment alone (2 \ m=x\ 15 \g=m\g/day for 9 days) had no effect on the prostaglandin F (PGF) concentration in uterine caruncles or intercaruncular tissue, on the release of PGF or of 13,14-dihydro-15-oxo PGF (PGFM) from these tissues during incubation in vitro, or on the concentrations of PGF in the utero-ovarian vein or PGFM in the jugular vein. However, oestradiol did accumulate in the uterine tissues. Progesterone treatment alone (2 \ m=x\10 mg/day for 9 days) provoked a significant increase in the concentration of PGF in the caruncles, a significant increase in the release of PGF from the caruncles during incubation with arachidonic acid and increased mean concentrations of PGFM in the jugular vein. When oestradiol was superimposed on a progesterone-primed system, there was a further marked increase in the PGF content of the caruncles, release of PGF into the utero-ovarian vein, and increased concentrations of PGFM in the jugular vein. The caruncles always contained more PGF than the intercaruncular area, and released more PGF and PGFM during incubation in vitro. In the progesterone+oestradiol group, there was good correlation between the PGF concentrations in simultaneous samples from the right and left utero-ovarian veins, and for all groups there was a high correlation between utero-ovarian PGF and peripheral PGFM concentrations. The caruncular epithelium of the progesterone-treated animals contained more lipid droplets than those of the other groups.These data are consistent with a requirement for progesterone in activating 'prostaglandin synthetase' activity, and promoting PGF production, largely from the caruncles. After progesterone priming, the synthesis of PGF by the caruncles and PG release into the vascular system was increased further by oestradiol treatment, whereas oestradiol alone was without effect.

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Prostaglandins F in Uterine Venous Plasma, Ovarian Arterial and Venous Plasma and in Ovarian and Luteal Tissue of Pregnant and Nonpregnant Ewes

Cited by 60 publications

References 17 publications

Hormone involvement in the establishment of pregnancy

Hormone involvement in the establishment of pregnancy

Functional Importance of Bovine Myometrial and Vascular LH Receptors and Cervical FSH Receptors

EFFECTS OF EXOGENOUS PROGESTERONE AND OESTRADIOL ON PROSTAGLANDIN F AND 13,14-Dihydro-15-Oxo PROSTAGLANDIN F2α CONCENTRATIONS IN UTERI AND PLASMA OF OVARIECTOMIZED EWES

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