Prostaglandins E1 and E2 stimulate release of intestinal brush border enzymes

Mirhom, R.; Eloy, R.; Vaultier, J.P.; Ananna, A; Clendinnen, Guy; Grenier, J F

doi:10.1016/0090-6980(77)90261-1

Cited by 15 publications

(4 citation statements)

References 24 publications

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“…PGEz, which is present in largequantities in human milk, has numerous effects on the gastrointestinal tract, including gastrointestinal cytoprotection (40), promotion of intestinal mucosal and cellular integrity (41), and the ability to increase intestinal motility (42) and release brush border enzymes (43). Our experiments showed that sIgA-anti-IgA complexes were able to induce secretion of PGEz from the HMM, thus implying that this mediator may have a local protective role on the developing neonatal gastrointestinal tract.…”

Section: Resultsmentioning

confidence: 99%

Identification of a Secretory IgA Receptor on Breast-Milk Macrophages: Evidence for Specific Activation Via These Receptors

1991

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ABSTRACT. Binding of secretory IgA (sIgA) to human milk macrophages was identified by rosette formation with sIgA-sensitized indicator cells and competitive inhibition binding studies with P 25 I)_sIgA. Macrophages formed rosettes with sIgA-sensitized sheep red blood cells that were inhibited by sIgA (87%) but not IgG. Both IgA) and IgA 2 inhibited sIgA-sensitized sheep red blood cell rosette formation. Rosette formation was completely inhibited by galactose, partially inhibited by asialofetuin, and unaffected by mannose. ( J25I)-labeled sIgA binding to macrophages reached a plateau after 60 min, was dependent on the number of macrophages in culture, and was specifically inhibited by unlabeled sIgA. Incubation of macrophage monolayers with increasing concentrations of sIgA-antiIgA immune complexes resulted in a progressive increase in the oxidative burst and increased secretion of prostaglandins. These studies indicate that human milk macrophages have a receptor for sIgA and that activation of these macrophages may occur via these receptors. (Pediatr Res 29: 429-434, 1991)

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Section: Resultsmentioning

confidence: 99%

Identification of a Secretory IgA Receptor on Breast-Milk Macrophages: Evidence for Specific Activation Via These Receptors

1991

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“…Whether or not the ALPase is released from the cells as a secretory protein either to the lumen of the intestine or to the interstitial space remains to be clarified. However, the possibility that ALase may also be a secretory protein in addition to being a component of plasma membrane is suggested by the report (13) that the activity of soluble ALPase was increased in the intestinal lumen when stimulated with prostaglandins El and E2.…”

Section: Discussionmentioning

confidence: 99%

Immunocytochemical and enzyme-cytochemical localization of intestinal alkaline phosphatase of rats.

Aihara

Nishimura

Yoshimura

et al. 1982

Acta Histochem. Cytochem

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“…Prostaglandins affect various physiological functions of the gastrointestinal tract including gastric secretion (28) and release of brush border enzymes (29). They also exert a potent secretory effect on the intestinal epithelium (28) and increase intestinal motility (3 1).…”

Section: Discussion Lactoferrin (M)mentioning

confidence: 99%

Lactoferrin Inhibits Prostaglandin E2 Secretion by Breast Milk Macrophages

1987

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ABSTRACT. The interaction between human breast milk macrophages and lactoferrin (LF) in its native form was studied in in vitro culture. Competitive inhibition-binding studies with 12"-LF and unlabeled LF showed that a specific receptor for LF was present on breast milk macrophages. LF at concentrations of 10-6-10-% resulted in a dose-dependent inhibition of prostaglandin E2 secretion by breast milk macrophages (control -45 f 7; LF M -9 2 1 ng/ml/106 cells). This inhibitory effect was also observed when the macrophages were stimulated with Concanavalin A (LF M -80 f 5; M -45 f 8 %inhibition of prostaglandin E, secretion by Concanavalin A stimulated macrophages). Lactalbumin and lactoglobulin had no effect. Similar concentrations of L F had no effect on lysozyme production. We also demonstrated that human milk macrophages are capable of eliciting an oxidative burst as measured by superoxide or hydrogen peroxide production when stimulated by phorbol myristate acetate in in vitro culture. (basal superoxide -1.4 f 0.3; phorbol myristate acetate 28.8 f 3.5 nmol/l x lo6 cells/9O min; basal hydrogen peroxide 11.7 f 4.6; phorbol myristate acetate -57.5 2 2.3 nmollmg protein/90 min). LF had no effect on the oxidative burst. These results suggest that interaction of aqueous and cellular components of breast milk may occur and result in varied physiological effects. (Pediatr Res 21: 54-57, 1987)

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Prostaglandins E1 and E2 stimulate release of intestinal brush border enzymes

Cited by 15 publications

References 24 publications

Identification of a Secretory IgA Receptor on Breast-Milk Macrophages: Evidence for Specific Activation Via These Receptors

Identification of a Secretory IgA Receptor on Breast-Milk Macrophages: Evidence for Specific Activation Via These Receptors

Immunocytochemical and enzyme-cytochemical localization of intestinal alkaline phosphatase of rats.

Lactoferrin Inhibits Prostaglandin E2 Secretion by Breast Milk Macrophages

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