Prostaglandins as mediators for the responses of the eye to trauma

Effect of Simultaneous CGRP and PGF_2α on the Outflow Facility in the Rabbit Eye

“…In rabbits, unlike most other species, prostaglandins have proved to elicit an irritative response including an increased IOP, anterior uveal vasodilatation, breakdown of the blood-aqueous barrier and miosis [7]. This seems however, to be markedly dose-dependent.…”

“…Higher doses of prostaglandins in the rabbit eye led early investigators to conclude that their main effects are connected with increased IOP and breakdown of the blood-aqueous barrier [6][7]. However, this seems to apply only to the rabbit eye, which is perhaps the most sensitive to various noxious stimuli [8].…”

THE EFFECTS OF SENSORY DENERVATION ON THE RESPONSES OF THE RABBIT EYE TO PROSTAGLANDIN E1, BRADYKININ AND SUBSTANCE P

“…that to scratching or laser irradiation of the iris (Ambache, Kavanagh & Whiting, 1965;Cole & Unger, 1973; which has hitherto been designated as prostaglandin-mediated would seem necessarily to include this nervous component.…”

Prostaglandins involved in contractions by angiotensin II and bradykinin of isolated dog sphincter pupillae

“…The sphincter muscles are contracted physiologically by activation of cholinergic nerves; electrical stimulation of the nerves and acetylcholine markedly contract the isolated sphincter muscle preparation (Yamauchi et al, 1973;Ueda et al, 1981;Narita & Watanabe, 1981). However, prostaglandins and thromboxane B2 (TXB2) have been chemically detected in the bovine iris, choroid and ciliary body (Fujiwara, 1983), and active metabolites of arachidonic acid produced by the cyclo-oxygenase pathway are considered to modulate the function of uveal tissues and to be involved in functional disorders, such as inflammation and trauma (Beitch & Eakins, 1969;Cole & Unger, 1973;Eakins, 1977;Unger et al, 1977;Bhattacherjee, 1980).…”