Prostaglandins and skin

Hensby, C.N.; Kingston, W.P.; Greaves, M.W.

doi:10.1111/j.1365-2230.1976.tb01446.x

Cited by 5 publications

(2 citation statements)

References 20 publications

(14 reference statements)

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“…i). Thehistory of the prostaglandins and some aspects of their relevance to skin were reviewed in this journal by Hensby, Kingston & Greaves (1976).…”

Section: Suminarymentioning

confidence: 99%

Prostaglandins, hydroxy fatty acids, leukotrienes and inflammation of the skin

Camp

1982

Clin Exp Dermatol

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Summary There is good evidence that prostaglandins E2, I2 and D2 are mediators of the vascular events of experimentally induced acute inflammation in human skin, but their role in inflammatory skin diseases such as atopic eczema remains to be determined. The relevance of arachidonic acid metabolites in inflammation has been expanded by the recent discovery of many biologically active arachidonate lipoxygenase products. These include monohydroxy fatty acids and a dihydroxy acid (leukotriene B4), which, especially in the latter case, are potent chemotactic agents. Other products include leukotriene C4 and D4, which are vasoactive and appear to be the functionally critical components of slow reacting substance of anaphylaxis. Much work is needed to determine the role of these compounds in inflammatory skin diseases.

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“…i). Thehistory of the prostaglandins and some aspects of their relevance to skin were reviewed in this journal by Hensby, Kingston & Greaves (1976).…”

Section: Suminarymentioning

confidence: 99%

Prostaglandins, hydroxy fatty acids, leukotrienes and inflammation of the skin

Camp

1982

Clin Exp Dermatol

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“…The known pharmacology of many prostanoids (products of the prostaglandin cyclo-oxygenase system) including vasodilatation and synergism with other inflammatory mediators (Hensby, Kingston & Greaves, 1976;Camp, 1982) would suggest a role for prostanoids in various human skin diseases, particularly those associated with an inflammatory component. We now report the preliminary results that we have obtained for the recoverable levels of four prostanoids, namely PGE2, PGD2, PGFja, and 6-oxo-PGFia in four human skin disorders, viz.…”

mentioning

confidence: 99%

Prostaglandins in human skin disease

Hensby¹,

Shroot²,

Schaefer³

et al. 2006

British Journal of Dermatology

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A variety of different, experimentally induced human skin inflammatory stimuli including UV‐A (Barr et al., 1982a; Gilchrest et al., 1982), UV‐B (Black et al., 1978, 1980; Hensby et al., 1980; Black, Hensby & Greaves, 1982), UV‐C (Camp et al., 1978), infra‐red (Hensby et al., 1982), trafuril (Plummer et al., 1977) and anthralin (Barr et al., 1982b) cause marked and prolonged elevations of the recoverable levels of arachidonic acid and its cyclo‐oxygenase products. The known pharmacology of many prostanoids (products of the prostaglandin cyclo‐oxy‐genase system) including vasodilatation and synergism with other inflammatory mediators (Hensby, Kingston & Greaves, 1976; Camp, 1982) would suggest a role for prostanoids in various human skin diseases, particularly those associated with an inflammatory component. We now report the preliminary results that we have obtained for the recoverable levels of four prostanoids, namely PGE2, PGD2, PGF2x, and 6‐oxo‐PGF1x in four human skin disorders, viz. psoriasis, tuberculin delayed hypersensitivity, vitiligo and scleroderma.

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Influence of intercellular agents on proliferation and gene activity of cultured human skin epithelium cells (NCTC 2544)

Reimer

Mentzer

et al. 1981

Arch Dermatol Res

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"Human skin epithelium cells" (NCTC strain 2544; HSEpicell) are established cells and grow to a monolayer the same way as epithelial cells. Addition of proliferating or antiproliferating substances results in a typical dose-dependent influence on the cell growth: steroids inhibit mitosis, polyamines stimulate proliferation, while prostaglandin E2, theophylline and papaverine reduce cell growth. Since the pattern of chromosomal nonhistone proteins indicates alterations of gene activity, DNA-binding proteins of HSE picells are analysed. Compared to native human skin fibroblasts (La Col 1115) there are only slight differences, in contrast to cancer cells. Therefore HSE picells may represent undifferentiated non-cancer cells. Hydrocortisone and theophylline inhibit cell proliferation by different mechanisms. As indicated by the pattern of DNA-binding proteins, both substances also act on HSEpicells in two different ways. As HSEpicells can be used for studying cell regulation, water-soluble extract and DNA-binding proteins of psoriatic scales as well as sera of psoriasis patients are tested in respect to any proliferating component. However, no influence on cell proliferation could be found.

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Prostaglandins and skin

Cited by 5 publications

References 20 publications

Prostaglandins, hydroxy fatty acids, leukotrienes and inflammation of the skin

Prostaglandins, hydroxy fatty acids, leukotrienes and inflammation of the skin

Prostaglandins in human skin disease

Influence of intercellular agents on proliferation and gene activity of cultured human skin epithelium cells (NCTC 2544)

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