Prostaglandins and reproduction in female farm animals

Weems, C.W.; Weems, Y.S.; Randel, R.D.

doi:10.1016/j.tvjl.2004.11.014

Cited by 281 publications

(192 citation statements)

References 360 publications

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“…Whether PGs have direct effects on follicular growth prior to the LH surge to initiate ovulation in livestock is unknown, but PGF 2α increases pituitary responsiveness to GnRH to release LH in the postpartum cow (Weems et al, 2006). A very high proportion of cows detected in oestrus by pedometer showed mounting lesions.…”

Section: Discussionmentioning

confidence: 99%

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Marı́n

Sánchez

Vizuete

et al. 2015

Acta Veterinaria Hungarica

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This trial evaluated the reproductive performance in an early routine oestrus induction programme using two different PGF 2α preparations in dairy cattle. D-cloprostenol sodium (n = 192; Group A) or dinoprost (n = 187; Group B) was administered between days 35 and 42 post partum. Also, a group of non-treated cows (n = 135; Group C) was included as control. Pedometers were used to detect oestrus, and also secondary oestrous signs and vaginal mucus quality were assessed prior to artificial insemination (AI). When oestrus was not detected for 14 days after PGF 2α administration, the treatment was repeated, up to a maximum of three times. There were no differences between the study groups in oestrus detection (A = 73.48%, B = 73.01%, C = 79.26%; P = 0.428), good mucus quality (A = 96.45%, B = 91.30%, C = 93.45%; P = 0.203) and the presence of mounting lesions (A = 98.58, B = 94.93%, C = 98.13; P = 0.414). First-service pregnancy rates were 19.78%, 15.64% and 32.03% in Groups A, B and C, respectively (P = 0.003). There were no inter-group differences for the interval from parturition to first AI. However, a significantly shorter interval from parturition to conception (92.17 days, 99.45 days, 118.93 days; P = 0.002) and significantly less services per conception (2.12, 2.18, 2.66; P = 0.003) were observed in Groups A and B in comparison with Group C. The use of PGF 2α resulted in better fertility in a repetitive, routine postpartum programme, although no differences between Dcloprostenol and dinoprost were detected.

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Section: Discussionmentioning

confidence: 99%

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Marı́n

Sánchez

Vizuete

et al. 2015

Acta Veterinaria Hungarica

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“…PGs) and recruitment of immune cells to the uterine endometrium (Jabbour et al 2009). PGE 2 (a vasodilator) is luteotrophic for maintaining progesterone secretion by the corpus luteum, whereas PGF 2α (a vasoconstrictor) is luteolytic (Weems et al 2006). In PG production pathways, two series PGs, such as PGE 2 and PGF 2α , are produced from arachidonic acid (AA).…”

Section: Introductionmentioning

confidence: 99%

BVDV alters uterine prostaglandin production during pregnancy recognition in cows

Cheng¹,

Abudureyimu²,

Oguejiofor³

et al. 2016

Reproduction

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Embryonic mortality in cows is at least in part caused by failure of pregnancy recognition (PR). Evidence has shown that bovine viral diarrhoea virus (BVDV) infection can disrupt pregnancy. Prostaglandins (PG) play important roles in many reproductive processes, such as implantation. The aim of this study was to investigate the effect of BVDV infection on uterine PG production and PR using an in vitro PR model. Bovine uterine endometrial cells isolated from ten BVDV-free cows were cultured and treated with 0 or 100 ng/mL interferon-τ (IFNT) in the absence or presence of non-cytopathic BVDV (ncpBVDV). PGF 2α and PGE 2 concentrations in the spent medium were measured using radioimmunoassays, and in the treated cells expression of the genes associated with PG production and signalling was quantified using qPCR. The results showed that the IFNT challenge significantly stimulated PTGS1 and PTGER3 mRNA expression and PGE 2 production; however, these stimulatory effects were neutralised in the presence of ncpBVDV infection. ncpBVDV infection significantly increased PTGS1 and mPGES1 mRNA expression and decreased AKR1B1 expression, leading to increased PGE 2 and decreased PGF 2α concentrations and an increased PGE 2 :PGF 2α ratio. The other tested genes, including PGR, ESR1, OXTR, PTGS2, PTGER2 and PTGFR, were not significantly altered by IFNT, ncpBVDV or their combination. Our study suggests that BVDV infection may impair PR by (1) inhibiting the effect of IFNT on uterine PG production and (2) inducing an endocrine switch of PG production from PGF 2α to PGE 2 to decrease uterine immunity, thereby predisposing the animals to uterine disease.Reproduction (2016) 151 605-614

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“…In mares, the average day of transition from preluteolysis to luteolysis is Day 14 (Day 0 ϭ ovulation), based on collection of hourly blood samples [3]. Secretion of PGF2␣ pulses by the endometrium has a fundamental role in luteolysis in mares [2,3] as in other species [4,5].…”

Section: Introductionmentioning

confidence: 99%

Ovarian and PGF2α responses to stimulation of endogenous PRL pulses during the estrous cycle in mares

Pinaffi¹,

Khan²,

Silva

et al. 2012

Theriogenology

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Prostaglandins and reproduction in female farm animals

Cited by 281 publications

References 360 publications

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

BVDV alters uterine prostaglandin production during pregnancy recognition in cows

Ovarian and PGF2α responses to stimulation of endogenous PRL pulses during the estrous cycle in mares

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