Prostaglandins and Migraine

Horrobin, D. F.

doi:10.1111/j.1526-4610.1977.hed1703113.x

Cited by 49 publications

(20 citation statements)

References 27 publications

(32 reference statements)

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“…However, from a metropolitan city of India, sexual activity as migraine trigger has been reported [2]. Menstruation‐related migraine is attributed to drop in serum estradiol [7] and prostaglandin level [8]. Diet has been reported to be an important trigger.…”

Section: Discussionmentioning

confidence: 99%

A Study of Triggers of Migraine in India

Yadav

Kalita

2010

Pain Med

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Section: Discussionmentioning

confidence: 99%

A Study of Triggers of Migraine in India

Yadav

Kalita

2010

Pain Med

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“…In particular, estrogen has potent effects on the serotonergic system, increasing serotonergic tone. Prostaglandins have also been implicated in MM [73]. In particular, entry of prostaglandins into the systemic circulation can trigger throbbing headache, nausea, and vomiting [74].…”

Section: Mechanisms Linking Sex Hormones and Migrainementioning

confidence: 99%

Migraine in women: the role of hormones and their impact on vascular diseases

et al. 2012

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Migraine is a predominantly female disorder. Menarche, menstruation, pregnancy, and menopause, and also the use of hormonal contraceptives and hormone replacement treatment may influence migraine occurrence. Migraine usually starts after menarche, occurs more frequently in the days just before or during menstruation, and ameliorates during pregnancy and menopause. Those variations are mediated by fluctuation of estrogen levels through their influence on cellular excitability or cerebral vasculature. Moreover, administration of exogenous hormones may cause worsening of migraine as may expose migrainous women to an increased risk of vascular disease. In fact, migraine with aura represents a risk factor for stroke, cardiac disease, and vascular mortality. Studies have shown that administration of combined oral contraceptives to migraineurs may further increase the risk for ischemic stroke. Consequently, in women suffering from migraine with aura caution should be deserved when prescribing combined oral contraceptives.Electronic supplementary materialThe online version of this article (doi:10.1007/s10194-012-0424-y) contains supplementary material, which is available to authorized users.

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“…62 Prostaglandins have also been implicated in menstrual migraine. 63 In particular, entry of prostaglandins into the systemic circulation can trigger throbbing headache, nausea and vomiting. 64 In the uterus prostaglandins are synthesised primarily by the endometrium.…”

Section: Other Mechanismsmentioning

confidence: 99%

Menstrual migraine: a clinical review

MacGregor¹

2007

j fam plann reprod health care

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OverviewMigraine attacks are often associated with menstruation in many, but not all, women with migraine. To date, no hormonal abnormalities have been identified in these women and it appears that normal hormonal fluctuations are associated with an abnormal central nervous system response. Diagnosis of migraine and confirmation of menstrual association is clinical, based on headache history and review of diary cards. Tests of hormone levels are rarely useful. Standard drugs to treat the acute symptoms suffice for the majority of women with monthly attacks. If acute therapy alone is inadequate, pre-emptive treatment of the expected menstrual headache with perimenstrual estradiol, triptans or non-steroidal anti-inflammatory drugs (NSAIDs) may be effective. Suppression of the menstrual cycle with anovulatory contraceptive agents is an additional option, particularly for women who also require contraception. A variety of other treatments have been studied, but the quality of evidence for their use is generally poor. Search strategyData for this review were identified by a MEDLINE search using the following search terms: estrogen, estradiol, menstruation, menstrual cycle, menstrual migraine, menstrually related migraine, menstrually associated migraine, migraine and progesterone. The resultant search identified 554 publications. The Cochrane search strategy for identifying reports of randomised controlled trials was run on this database. 1 The search strategy identified 103 publications, which were scrutinised for relevancy to this review.In addition, references from the author's own files, a hand search of the journals Cephalalgia and Headache, and peer-reviewed presentations at international congresses were considered. How common is migraine?The two most frequently encountered types of migraine differ only in their presence or absence of 'aura' (Box 1). 2 About 70-80% of migraineurs experience attacks of migraine without aura (formerly known as common or simple migraine), 10% have migraine with aura (formerly known as classical or focal migraine) and 15-20% have both types of attacks. Less than 1% of attacks are of aura alone, with no ensuing headache.Migraine is equally common in both sexes before puberty, with increased female prevalence following menarche. 3 At puberty, the incidence of migraine without aura rises in females, 4 with 10% to 20% of women reporting migraine with menarche. 5 This sex difference becomes greater with increasing age, peaking during the early 40s and declining thereafter. The lifetime prevalence of migraine is around 25% in women compared to only 8% in men. [6][7][8]

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Prostaglandins and Migraine

Cited by 49 publications

References 27 publications

A Study of Triggers of Migraine in India

A Study of Triggers of Migraine in India

Migraine in women: the role of hormones and their impact on vascular diseases

Menstrual migraine: a clinical review

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