Prostaglandin synthetase activity of goat vesicular microsomes: Co-factor requirement and effect of calcium ions

Gosh, Dolly; Dutta, J.C.

doi:10.1007/bf02702576

Cited by 4 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous observations have indicated that prostaglandin synthesis in the kidney, as in other tissues, is a C a + + dependent process. The influence of Ca+ + on prostaglandin synthesis may be mediated through an action of this cation to stimulate the release of free arachidonate from tissue lipid stores by activation of the enzyme phospholipase A2 (Kalisker and Dyer, 1972;Wentzell and Epand, 1978;Craven et al, 1980;Gosh and Dutta, 1982). It has also been suggested that increase in cytosolic Ca+ + derived from extracellular and intracellular pools may represent a common pathway through which the action of various stimuli initiate arachidonic acid release to subsequent conversion to prostaglandin (Zenser and Davies, 1978;Craven et a/., 1982).…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Experimental Nephrocalcinosis with a Prostaglandin Synthetase Inhibitor

Buck

Leaker

et al. 1983

British Journal of Urology

View full text Add to dashboard Cite

Nephrocalcinosis was induced in a group of experimental rats by means of intraperitoneal injections of 10% calcium gluconate. Two further groups of rats were treated with indomethacin and flurbiprofen (Froben) before receiving the i.p. calcium gluconate, to study the effects of prostaglandin inhibition on the process of renal parenchymal calcification. Tissue calcification was studied by means of contact microradiography and histology. Quantitative calcium analysis was by means of energy dispersive analysis of X-rays (EDAX). There was a marked inhibition of cortical nephrocalcinosis and a significantly reduced calcium concentration (P less than 0.005) in the animals treated with a prostaglandin inhibitor compared with the animals given i.p. calcium gluconate alone. This study suggests that prostaglandins are involved in the process of renal parenchymal calcification and may be aetiologically significant in the pathogenesis of stone formation.

show abstract

Section: Discussionmentioning

confidence: 99%

Inhibition of Experimental Nephrocalcinosis with a Prostaglandin Synthetase Inhibitor

Buck

Leaker

et al. 1983

British Journal of Urology

View full text Add to dashboard Cite

show abstract

The Inhibition of Experimental Nephrocalcinosis with A Prostaglandin Synthetase Inhibitor

Buck¹

1985

Urolithiasis and Related Clinical Research

View full text Add to dashboard Cite

Synthesis of diene prostaglandins in freshwater fish

Bandyopadhyay

Dutta

Ghosh

1982

Lipids

View full text Add to dashboard Cite

Biosynthesis of PGD2, PGE2 and PGF2 alpha in four species of freshwater fish, Tilapia mossambica, Cyprinus carpio, Heteropneustes fossilis and Clarius batrachus was studied. Both arachidonic acid and PGH2 were used as substrates. When PGH2 replaced arachidonic acid in the enzymic reaction, there was a 3- to 4-fold increase in PGE2 synthesis, but no such increase in the synthesis of PGF2 alpha and PGD2 was observed.

show abstract

Prostaglandin synthetase activity of goat vesicular microsomes: Co-factor requirement and effect of calcium ions

Cited by 4 publications

References 15 publications

Inhibition of Experimental Nephrocalcinosis with a Prostaglandin Synthetase Inhibitor

Inhibition of Experimental Nephrocalcinosis with a Prostaglandin Synthetase Inhibitor

The Inhibition of Experimental Nephrocalcinosis with A Prostaglandin Synthetase Inhibitor

Synthesis of diene prostaglandins in freshwater fish

Contact Info

Product

Resources

About