“…These observations led to the hypothesis that activated microglia promote the progression of diet-induced obesity (DIO) and insulin resistance (Ávalos et al, 2018; Berkseth et al, 2014; Douglass et al, 2017a; Schur et al, 2015; Thaler et al, 2012; Valdearcos et al, 2015, 2019). Indeed, there is now substantial evidence that microglia increase DIO susceptibility (Dorfman et al, 2017; Gao et al, 2017; Kim et al, 2019; Niraula et al, 2021; Valdearcos et al, 2014, 2017; Wang et al, 2020), but a weight-independent role for microglia in glucose homeostasis has not been established.…”