Prostaglandin modulation of mouse and human sperm capacitation

Herrero, Marı́a Belén; Viggiano, J.M.; Boquet, M.; Gimeno, M.F.

doi:10.1016/s0952-3278(97)90545-7

Cited by 13 publications

(8 citation statements)

References 15 publications

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“…PGs, such as PGE and PGF 2 α, are primarily produced in the accessory glands of the reproductive tract and have been shown to affect motility [1,3,4,17], acrosome reaction [15,16], capacitation, and fertilizing ability of sperm [8,15]. The present results revealed that PGE 2 production was dramatically increased not in serum but in seminal plasma immediately following ejaculation in male dogs.…”

mentioning

confidence: 47%

Changes in Prostaglandin E2 Levels in Seminal Plasma during Ejaculation and the Effect of Exogenous Prostaglandin E2 on Semen Volume in the Dog

Kobayashi

Hori

Kawakami

2013

The Journal of Veterinary Medical Science

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In healthy male dogs, peripheral plasma testosterone (T), prostaglandin E2 (PGE2) and seminal plasma PGE2 levels were measured before, during and after ejaculation, and semen quality was examined after oral administration of PGE2. Plasma T and PGE2 levels did not change during these periods, but the seminal plasma PGE2 level of combined the first and second fractions was significantly higher than those at 0-5 and 5-10 min after the start of ejaculation of the third fraction. Semen volume but not quality increased after PGE2 administration. In conclusion, large amounts of PGE2 are released from the prostate gland during the early part of ejaculation, and PGE2 plays an essential role in secretion of seminal plasma.

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mentioning

confidence: 47%

Changes in Prostaglandin E2 Levels in Seminal Plasma during Ejaculation and the Effect of Exogenous Prostaglandin E2 on Semen Volume in the Dog

Kobayashi

Hori

Kawakami

2013

The Journal of Veterinary Medical Science

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“…and C.D.K., unpublished), suggesting that ejaculate-derived PGE 2 has a positive effect on both egg development and oviposition. From the male perspective, prostaglandins play various roles in sperm maintenance in mammals, including sperm motility (Didolkar and Roychowdhury, 1980), viability (Hayashi et al, 1988), protection from phagocytosis (Marey et al, 2013), and enhancing the acrosome reaction necessary for the fusion of sperm and egg (Herrero et al, 1997). To our knowledge, there are no studies examining the importance of prostaglandin on sperm maintenance in insects, so further research will be required to understand these effects.…”

Section: Discussionmentioning

confidence: 99%

“…Prostaglandins are oxygenated metabolites of C 20 polyunsaturated fatty acids that are fundamental to many aspects of animal physiology (Craig, 1975;Harris et al, 2002;Wolfe and Coceani, 1979) and are found in the ejaculates of various animals (Kennedy et al, 2003;Kobayashi et al, 2013;Loher et al, 1981;Templeton et al, 1978). The biological significance of prostaglandins in mediating physiological actions essential for reproduction is well understood in mammals (Didolkar and Roychowdhury, 1980;Herrero et al, 1997;Kurzrok and Lieb, 1930;Marey et al, 2013), and is considered to be important in invertebrate reproduction as well. Prostaglandins are found in cricket seminal fluid (Loher et al, 1981) and have noted effects on the reproductive physiology of two species, Teleogryllus commodus and Acheta domesticus, in mediating egg production and oviposition in mated females (Loher and Edson, 1973;Murtaugh and Denlinger, 1985).…”

Section: Introductionmentioning

confidence: 99%

Mating for male-derived prostaglandin: a functional explanation for the increased fecundity of mated female crickets?

Worthington

Jurenka

Kelly

2015

Journal of Experimental Biology

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Direct benefits are considered to be the driving force of high female mating rates, yet species in which females do not receive material resources from males still experience increased fitness from mating frequently. One hypothesis suggests that substances within the ejaculate may boost survival or offspring production. If these materials are limiting to females, they will require continual renewal via mating and could provide a functional understanding of how high mating rates lead to increased female fitness. Using the Texas field cricket, Gryllus texensis, we investigated the sexual transfer of prostaglandin E 2 , an important mediator of invertebrate reproduction. We determined that like other gryllid species, males include significant quantities of prostaglandin E 2 (PGE 2 ) and its precursor molecule, arachidonic acid (AA), within the spermatophore. These components are passed to females during copulation and then stored within the spermatheca. We then tested the novel hypothesis that PGE 2 is ephemerally available after mating and that females must frequently mate to maintain access to this limiting compound. We found that PGE 2 within the spermatheca is indeed depleted through time, with only a small amount remaining 1 week after mating, but that its presence can be maintained at high quantities and for prolonged periods of time by remating. Our results support the hypothesis that high female mating rates increase the amount and availability of PGE 2 throughout the breeding season, which could explain the positive relationship between female mating rate and fecundity.

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“…For mammals, seminal PG are produced mainly in the accessory glands of the reproductive tract, and PG have been shown in vitro to affect sperm motility, capacitation, and the acrosome reaction [16-18,27-29]. In contrast, avian species do not have accessory glands, nor do avian spermatozoa undergo capacitation or a mammalian-like acrosome reaction.…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility

Kennedy

Korn

Thurston

2003

Reprod Biol Endocrinol

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BackgroundTurkey reproduction is by artificial insemination using pooled semen so there is interest in storing semen. Fertilizing capacity declines after six hours storage, possibly due to poor sperm mobility. Prostaglandins (PG) affect mammalian sperm motility, but avian sperm has not been widely studied. For this study, levels of PG E1, E2, and F2 alpha in turkey seminal plasma and sperm extract, and effects of cyclooxygenase (COX) inhibitors on sperm mobility were determined.MethodsSeminal Plasma and sperm extract PG E1, E2, and F2 alpha, from 1.0 mL pooled semen, were measured by ELISA. In Trial 1, PG were determined from 122 wk old toms (n = 4). Trial 2 used 36 wk old toms (n = 7). For Trial 3, PGE2 only was measured from 48 wk (n = 6) and 154 wk old toms (n = 3). The effects of non-specific COX inhibitors indomethacin, diclofenac, tolmetin, or aspirin (n = 10), or specific COX-1 or COX-2 inhibitors (n = 3) on sperm mobility were measured (Accudenz swim-down test).ResultsSeminal plasma PG (pg/mL) in Trials 1 and 2, respectively, were 185.2 ± 88.4 and 187.2 ± 33.7 for PGE1; 141.4 ± 43.1 and 100.4 ± 14.6 for PGF2 alpha; and 431.0 ± 155.1 for PGE2 (Trial 1 only). Sperm extract PG (pg/10 billion cells) in Trials 1 and 2, respectively, were 215.1 ± 38.1 and 208.9 ± 41.5 for PGE1; 133.7 ± 51.7 and 49.8 ± 8.3 for PGF2 alpha; and 52.3 ± 8.6 for PGE2 (Trial 1 only). In Trial 3, seminal plasma PGE2 (pg/mL) in older versus younger males was 1097.9 ± 99.3 versus 853.2 ± 144.6 and sperm extract PGE2 (pg/10 billion cells) was 208.0 ± 56.1 versus 102.4 ± 14.8. Cyclooxygenase inhibitors (0.001 to 10 mM) decreased sperm mobility: indomethacin 15 to 100%; diclofenac 4 to 100%; tolmetin 27 to 74%; aspirin (tested at 0.01 to 15 mM) 22 to 42%; resveratrol (COX-1) and NS-398 (COX-2), both tested at 0.1 to 10 mM, 38 to 98% and 44 to 85%, respectively.ConclusionThese results indicate that PG are present in turkey seminal plasma and sperm, and COX inhibitors decrease turkey sperm mobility.

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Prostaglandin modulation of mouse and human sperm capacitation

Cited by 13 publications

References 15 publications

Changes in Prostaglandin E<sub>2</sub> Levels in Seminal Plasma during Ejaculation and the Effect of Exogenous Prostaglandin E<sub>2</sub> on Semen Volume in the Dog

Changes in Prostaglandin E<sub>2</sub> Levels in Seminal Plasma during Ejaculation and the Effect of Exogenous Prostaglandin E<sub>2</sub> on Semen Volume in the Dog

Mating for male-derived prostaglandin: a functional explanation for the increased fecundity of mated female crickets?

Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility

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