Prostaglandin involvement in hyperthermia induced by sleep deprivation: A pharmacological and autoradiographic study

Palma, Beatriz Duarte; Nóbrega, José N.; Gomes, Vinicius Carreteiro; Esumi, Lia Assae; Seabra, Maria L. V.; Tufik, Sérgio; Hipólide, Débora Cristina

doi:10.1016/j.lfs.2008.12.009

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…The treatment with selective COX‐2 inhibition by rofecoxib failed to decrease mucosal prostaglandin E2 levels in SD rats . Similar findings have been reported by others showing that SD did not show a positive response to the COX‐2 inhibitor as well as no alterations in prostaglandin E2 levels in rat brain . However, animals submitted to SD promoted an increase in iNOS expression, and the group submitted to SD96 + R, iNOS mRNA levels decreased.…”

Section: Discussionsupporting

confidence: 87%

“…27 Similar findings have been reported by others showing that SD did not show a positive response to the COX-2 inhibitor as well as no alterations in prostaglandin E2 levels in rat brain. 28 However, animals submitted to SD promoted an increase in iNOS expression, and the group submitted to SD96 + R, iNOS mRNA levels decreased. Some authors have demonstrated an increase of iNOS expression in testicular tissue from rats exposed to SD or sleep restriction for 21 days.…”

Section: Discussionmentioning

confidence: 96%

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Sleep deprivation induces pathological changes in rat masticatory muscles: Role of Toll like signaling pathway and atrophy

Yujra

Antunes

Mônico‐Neto

et al. 2017

J of Cellular Biochemistry

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The aim of this study was to evaluate the Toll like signaling pathway and atrophy after sleep deprivation (SD) in rat masticatory muscles: masseter and temporal. A total of 24 animals was distributed into three groups: Control group (CTL, n = 8), subjected to SD for 96 h (SD96, n = 8) and subjected to SD for 96 h more 96 h of sleep recovery (SD96 + R, n = 8). Histopathological analysis revealed the presence of acute inflammatory cells, congested vessels, fibrosis, and high cellularity in the skeletal muscle fibers from masseter and temporal submitted to SD. These morphological alterations were not observed in the control group since neither inflammatory cells nor congested vessels were observed to this group. In the group SD96 + R, the absence of inflammation was noticed to the masseter only. In this group, COX-2 and TNF-alpha downregulation were detected when comparing to control group. MyD88 and pIKK decreased in SD96 and SD96 + R groups being pNFKBp50 downregulatated in SD96 + R. MyD88 expression increased in rats submitted to SD96 and SD96 + R in temporal when compared to control group. On the other hand, pIKK decreased the protein expression in groups SD96 and SD96 + R while pNFKBp50 showed a decreased protein expression in group SD96 only. The activation of atrophy by means of MAFbx upregulation was detected in temporal muscle in SD96 and SD96 + R when compared to control. In summary, our results show that SD is able to induce morphological alterations in rat masticatory muscles. Toll like signaling pathway and atrophy play important roles in ethiopathogenesis induced by SD, being dependent of skeletal muscle type.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 96%

Sleep deprivation induces pathological changes in rat masticatory muscles: Role of Toll like signaling pathway and atrophy

Yujra

Antunes

Mônico‐Neto

et al. 2017

J of Cellular Biochemistry

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“…This may affect local auto-receptor adenosinemediated cholinergic cell inhibition of basal forebrain disrupting inhibition of GABAergic cells in the VLPO and stimulation of the hypocretin system eliciting experimentally observed effects on sleep indices. It would also be interesting to investigate whether the homeostatic dynamics of thermoregulatory mechanism (Morrison and Nakamura 2011) and sleep-thermoregulation interaction (Sawka et al 1984;Rechtschaffen and Bergmann 2002;Oliver et al 2009;Palma et al 2009;Krauchi and Deboer 2010) has anything to do with sleep homeostasis.…”

Section: Neurophysiology Of Humidity Effect On Sleepmentioning

confidence: 99%

“…Prolonged sleep loss impairs temperature control (Rechtschaffen and Bergmann 2002) and SD studies have shown hyperthermic result (Sawka et al 1984;Palma et al 2009;Oliver et al 2009) though, Vaara (2009 had reported decreasing effect on temperature (measured from ears) with a 60 h SD protocol. Whatever may be the nature of the effect, the presence of effect in conjunction with above observations point to two-directional sleep-body temperature regulation dynamics (Figure 4) though, more studies with other sleep loss models will make the picture still clearer.…”

Section: Thermo-physiology Of Humidity Effect On Sleepmentioning

confidence: 99%

Humidity and sleep: a review on thermal aspect

Manzar

Sethi

Hussain

2012

Biological Rhythm Research

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The peripheral humidity detector/detection is not clear though there are comprehensive reports of subjective perception. High relative humidity at ambient temperatures above thermo-neutral zone has deleterious effect on sleep. Humidity affects heat transfer rate by affecting evaporation and thereby disturbing the Tc and Ts dynamics. The effect is discernible across a host of sleep, body temperature, and microclimate indices. A number of hypotheses have been proposed to explain the sleep structure regulation of which circadianhomeostatic interaction model is the most accepted one. Humid heat may affect sleep through homeostatic pathway possibly interfering with adenosine accumulation in basal forebrain and thereby affecting non-rapid eye movement (NREM) sleep switch point. It may also have a circadian element by interfering with thermo-regulatory feedback loop and/or by affecting Ts change input to sleep regulation.

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“…There are also studies showing that COX-2 inhibition is not greatly affected in sleep disorders. 27 Study limitations. It is an animal model and may not be match for human muscle.…”

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confidence: 99%

The histopathological effects of sleep disorders on striated muscle in rats

Çinar

Bozoğlan

Aytekin

et al. 2023

SMJ

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Objectives: To histopathologically examine the change in gastrocnemius muscle created by sleep disorder in rats.Methods: This study was carried out at Giresun University, Turkey from December 2018 to January 2021. A total of 30 Wistar rats were separated into 3 groups as the control group (CG), absence of rapid eye movement (REM) sleep (ARS) group, chronic absence of sleep (CAS) group. The lack of sleep was created in all rats. At the end of 21 days, all the rats were euthanized. Degeneration and regeneration findings, and expressions of muscle RING finger 1 (MuRF1), muscle atrophy F-box (MAFbx), tumor necrosis factor (TNF), cyclooxygenase 2 Original Article(COX 2), insulin-like growth factor 1 (IGF1) in the gastrocnemius muscles were evaluated histopathologically and immunohistochemically.Results: Degeneration was found to be greater in the ARS and CAS groups compared to the CG. Regeneration was determined to be significantly lower in the CAS group compared to the ARS group and control group. The number of atrophic fibres was greater in the CAS and ARS groups than in the control group. The IGF1 staining in the CAS group was found to be stronger than in the other 2 groups. Conclusion:This study demonstrated an increase in findings of degeneration in the gastrocnemius muscle of rats with a lack of sleep. The regeneration was reduced in the group with chronic lack of sleep.

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Prostaglandin involvement in hyperthermia induced by sleep deprivation: A pharmacological and autoradiographic study

Cited by 5 publications

References 23 publications

Sleep deprivation induces pathological changes in rat masticatory muscles: Role of Toll like signaling pathway and atrophy

Sleep deprivation induces pathological changes in rat masticatory muscles: Role of Toll like signaling pathway and atrophy

Humidity and sleep: a review on thermal aspect

The histopathological effects of sleep disorders on striated muscle in rats

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