Prostaglandin endoperoxides promote calcium release from a platelet membrane fraction in vitro

Gerrard, Jonathan M.; Butler, Alison; Graff, Gustav; Stoddard, S.F.; White, James G.

doi:10.1016/0161-4630(78)90124-6

Cited by 43 publications

(6 citation statements)

References 18 publications

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“…A preliminary study has indicated that the PGH2 analogue mobilizes primarily extracellular calcium and only a fraction of the intracellular calcium in rabbit aorta (Loutzenhizer & Van Breeman, 1980). This analogue (Gerrard, Butler, Graff, Stoddard & White, 1978), PGF2a (Carsten & Miller, 1977), and PGE2 (Carsten & Miller, 1978) have also been described as possessing Ca2+ ionophore activity. Defelice & Joiner (1975) have characterized a superficial store of calcium in the male aorta capable of binding three times more Ca2+ than in the female, as indicated by 45Ca2+ desaturation studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of Gender on Development and Diurnal Rhythm of Prostaglandin Receptors in Rat Aorta

Karanian¹,

Ramey²,

Ramwell³

1981

British J Pharmacology

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1 The prostaglandin endoperoxide H2 analogue, U-46619 (15-hydroxy-11, 9-epoxymethanoprosta-5Z, 13E-enoic acid), was used to determine the effect of gender on the isotonic contractile response of the superfused rat aorta preparation over a 24 h period and at 10 and 16 weeks of age. 2 The maximal responses of the male aortae were 20 ± 3% and 36 ± 4% (P< 0.001) greater than the female at 10 and 16 weeks, respectively. Similarly, sensitivity of the male aorta to the PGH2 analogue increased with age. 3 The male but not the female exhibited a diurnal rhythm in which both the maximum contractile response and sensitivity were significantly decreased at night. 4 We conclude that these gender differences may be related to the secretion of androgen, since reported peak serum testosterone over a 24 h period and testosterone changes with maturation are coincident with the maximum response of male aortae to the PGH2 analogue.

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Section: Discussionmentioning

confidence: 99%

Effect of Gender on Development and Diurnal Rhythm of Prostaglandin Receptors in Rat Aorta

Karanian¹,

Ramey²,

Ramwell³

1981

British J Pharmacology

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“…peroxides may act as Ca ionophores (1,4,8). After earlier suggestions that prostaglandins of the E and F series might themselves function as Ca ionophores (9)(10)(11), evidence was adduced that endoperoxide analogs mediate Ca transfer from aqueous to nonpolar solvents (12).…”

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confidence: 99%

“…Finally, dose-response comparison (Fig. 5 (10), and the endoperoxides (PGG2 and PGH2) promoted Ca release from a platelet membrane fraction (8). In each instance, millimolar concentrations of prostaglandins were required to produce effects comparable to micromolar concentrations of the carboxylic acid ionophore A23187 (8)(9)(10).…”

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A general method, employing arsenazo III in liposomes, for study of calcium ionophores: results with A23187 and prostaglandins.

Weissmann¹,

Anderson²,

Serhan³

et al. 1980

Proc. Natl. Acad. Sci. U.S.A.

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Multilamellar (MLV) and large unilamellar (LUV) lipid vesicles (liposomes) trap the metallochromic dye arsenazo III [2,7-bis(arsonophenylazo) naphthalene-3,6-disulfonic acid]; EGTA, ethylene glycol bis(f-aminoethyl ether)-N,N,N',N'-tetraacetic acid; TX-100, Triton X-100; prostaglandin endoperoxide analog 1, (5Z, 9a, 1la, 13E, 15s)-9,11-methanoepoxy-15-hydroxyprosta-5,13-dienoic acid; prostaglandin endoperoxide analog II, (5Z, 9a, 1 la, 13E, 15s)-9,11 epoxymethano-15-hydroxyprosta-5,13-dienoic acid; 9,1 1-azoprostanoid III, (5Z, 9a, lla, 13E, 15s)-9,11-azo-15-hydroxyprosta-5,13-dienoic acid; PG, prostaglandin; PGBX, polymeric derivative of PGBI; X2+, divalent cation. * As previously suggested (16), and agreed (17), a short-hand system of notation for liposomes will be employed. 1506The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.

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“…The response of smooth muscle to prostaglandins is well known to be calcium-dependent. The PGH2 analogue U46619 (Gerrard, Butler, Graff, Stoddard & White, 1978), as well as PGF2a (Carsten & Miller, 1977) and PGE2 (Carsten & Miller, 1978) appear to possess calcium ionophore activity. A preliminary report indicates that the analogue U46619 mobilizes extracellular calcium and only a fraction of the intracellular in rabbit aorta (Loutzenhiser & Van Breeman, 1980).…”

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confidence: 99%

Gender Differences in Prostaglandin Receptors of Rat Aorta

Karanian

Moran

Ramey

et al. 1981

British J Pharmacology

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The maximal contractile response to the prostaglandin endoperoxide H2 analogue U46619, prostaglandins E2, D2 and F25 and the sensitivity of the superfused aorta preparation to these drugs (except PGF2J) is greater in the male than the female rat. In contrast, gender differences were not observed in the response to noradrenaline or 5-hydroxytryptamine. In previous studies, testosterone unlike oestrogen or progesterone, increased the response of both rabbit and rat aorta to U46619. We conclude that prostaglandin receptors in rat thoracic aorta may be hormonally regulated.

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Prostaglandin endoperoxides promote calcium release from a platelet membrane fraction in vitro

Cited by 43 publications

References 18 publications

Effect of Gender on Development and Diurnal Rhythm of Prostaglandin Receptors in Rat Aorta

Effect of Gender on Development and Diurnal Rhythm of Prostaglandin Receptors in Rat Aorta

A general method, employing arsenazo III in liposomes, for study of calcium ionophores: results with A23187 and prostaglandins.

Gender Differences in Prostaglandin Receptors of Rat Aorta

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