Prostaglandin E2 correlates with histamine production in human colorectal cancer

Cianchi, Fabio; Cortesini, C; Perna, Federico; Fabbroni, Valentina; Uliva, Caterina; Fabrizi, Francesca; Giannini, Lucia; Vannacci, Alfredo; Masini, Emanuela

doi:10.1007/s00011-005-0053-x

Inflamm. res.

2006

DOI: 10.1007/s00011-005-0053-x

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Prostaglandin E2 correlates with histamine production in human colorectal cancer

Fabio Cianchi

C Cortesini

Federico Perna

et al.

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2008

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“…Histamine has recently been shown to be involved in the stimulation of angiogenesis in several types of human cancers (1, 2), besides its important roles in inflammation, gastric acid secretion, allergic reactions and neurotransmission (3, 4). The possible mechanisms of histamine in enhancing angiogenesis have been suggested to be related to the release of vascular endothelial growth factor (VEGF) (5) and COX‐2 (6, 7), which have been demonstrated to be mediated by H2 receptors in in vivo studies (8). Hence, inhibiting angiogenesis by blocking H2 receptors could be a strategy to arrest tumor growth.…”

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Expression of non‐mast cell histidine decarboxylase in tumor‐associated microvessels in human esophageal squamous cell carcinomas

Liu

Fuai

et al. 2008

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Histamine is produced by mast cells and many other types of cells. The role of histamine released from mast cells in promoting tumor angiogenesis has been intensively studied; however, the role of non-mast cell histamine in regulating tumor angiogenesis has been largely ignored. In this study, tissue specimen sections from 43 patients with esophageal squamous cell carcinoma (ESCC) and normal esophageal biopsies from 17 heath individuals obtained from a high incidence area of north China were used to assess changes in microvessel density (MVD) and non-mast cell L-histidine decarboxylase (HDC) (the only rate-limiting enzyme that catalyzes the formation of histamine from L-histidine) expression in the tumor microenvironment by immunohistochemistry (IHC). In addition, the cellular characterization of non-mast cell HDC-positive cells in microvessels was examined by double IHC combined with HDC/CD34 and HDC/PCNA antibodies. These IHC analyses revealed a significantly increased HDC-positive MVD in ESCC as compared with normal controls, which accounted for approximately 61% of CD34-labeled general MVD in ESCC. Furthermore, IHC in serial sections and double IHC showed that most of these HDC-positive cells were CD34-positive endothelial cells in microvessels with an increased proliferative capacity. Thus, our results suggest that non-mast cell histamine expressed in endothelial cells of microvessels could be an additional cellular source and might play a role in regulating angiogenesis in ESCC.

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confidence: 99%

Expression of non‐mast cell histidine decarboxylase in tumor‐associated microvessels in human esophageal squamous cell carcinomas

Liu

Fuai

et al. 2008

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The Influence of Mast Cell Mediators on Migration of SW756 Cervical Carcinoma Cells

et al. 2008

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Abstract. The role of mast cell mediators on cervical cancer cell migration was assessed using an in vitro assay of scratch wound healing onto monolayers of HPV18-positive cervical carcinoma cells (SW756). Migration of SW756 cells was accelerated by co-culture with the mast cell line LAD2. This effect was inhibited by the H1R antagonist pyrilamine and the cannabinoid agonists 2-arachidonylglycerol (2AG) and Win 55,212-2. Therefore, the specific effects of histamine and cannabinoids on SW756 migration and LAD2 activation were analyzed. Histamine added to the in vitro assay of scratch wound healing either increased or inhibited SW756 migration rate by acting either on H1R or H4R, respectively. Cannabinoids acted on CB1 receptors to inhibit SW756 migration. Supernatants from SW756 cells stimulated LAD2 cell degranulation, which in turn was inhibited by cannabinoids acting via CB2 receptors. RT-PCR showed that SW756 expressed mRNA for CB1, CB2, H1R, H2R, and H4R. On the other hand, LAD2 expressed mRNA for all four HRs and CB2. The results suggest that mast cells could be contributing to cervical cancer cell invasion and spreading by the release of histamine and cannabinoids. Therefore, therapeutic modulation of specific mast cell mediators may be beneficial for cervical cancer treatment.

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Prostaglandin E2 correlates with histamine production in human colorectal cancer

Cited by 2 publications

References 7 publications

Expression of non‐mast cell histidine decarboxylase in tumor‐associated microvessels in human esophageal squamous cell carcinomas

Expression of non‐mast cell histidine decarboxylase in tumor‐associated microvessels in human esophageal squamous cell carcinomas

The Influence of Mast Cell Mediators on Migration of SW756 Cervical Carcinoma Cells

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