Prostaglandin E<sub>2</sub>is a Potential Mediator of Extracellular ATP Action in Osteoblast-Like Cells

Suzuki, Atsushi; Kotoyori, Jun; Oiso, Yutaka; Kozawa, Osamu

doi:10.3109/15419069309095687

Cited by 24 publications

(9 citation statements)

References 18 publications

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“…In the osteoblast-like cell line MC3T3-E1, extracellular ATP stimulated Ca 2+ influx resulting in the release of arachidonic acid. This enhanced prostaglandin E2 synthesis and cell proliferation [186]. ATP or UTP equipotently stimulated release of [ 3 H]arachidonic acid from prelabeled primary cultures of human nasal epithelium and a cell line (BEAS39) derived from bronchial epithelium, presumably through the P2Y 2 R. Receptor activation triggered cytosolic Ca 2+ elevation and phospholipase A 2 activation.…”

Section: Lipid Mediatorsmentioning

confidence: 96%

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Zimmermann

2015

Purinergic Signalling

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Extracellular nucleotides, and ATP in particular, are cellular signal substances involved in the control of numerous (patho)physiological mechanisms. They provoke nucleotide receptor-mediated mechanisms in select target cells. But nucleotides can considerably expand their range of action. They function as primary messengers in intercellular communication by stimulating the release of other extracellular messenger substances. These in turn activate additional cellular mechanisms through their own receptors. While this applies also to other extracellular messengers, its omnipresence in the vertebrate organism is an outstanding feature of nucleotide signaling. Intercellular messenger substances released by nucleotides include neurotransmitters, hormones, growth factors, a considerable variety of other proteins including enzymes, numerous cytokines, lipid mediators, nitric oxide, and reactive oxygen species. Moreover, nucleotides activate or co-activate growth factor receptors. In the case of hormone release, the initially paracrine or autocrine nucleotide-mediated signal spreads through to the entire organism. The examples highlighted in this commentary suggest that acting as ubiquitous triggers of intercellular messenger release is one of the major functional roles of extracellular nucleotides. While initiation of messenger release by nucleotides has been unraveled in many contexts, it may have been overlooked in others. It can be anticipated that additional nucleotide-driven messenger functions will be uncovered with relevance for both understanding physiology and development of therapy.

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Section: Lipid Mediatorsmentioning

confidence: 96%

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Zimmermann

2015

Purinergic Signalling

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“…The mitogenic effects of ATP were first reported by Suzuki and colleagues in the early 1990's (Suzuki et al, 1993). Subsequent work showed that ATP acting via the P2X5 receptor promotes DNA synthesis in human osteoblast-like cells (Nakamura et al, 2000).…”

Section: P2x Receptors and Osteoblastsmentioning

confidence: 96%

The role of purinergic signalling in the musculoskeletal system

Orriss

2015

Autonomic Neuroscience

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“…ATP stimulates the proliferation of MC3T3-E1 osteoblastic cells, but whether this effect is mediated indirectly through enhanced synthesis of prostaglandins remains unclear [Suzuki et al, 1993;Shimegi, 1996]. In MC3T3-E1 cells, extracellular ATP also activates phospholipase D [Suzuki et al, 1995], leading to the release of arachidonic acid and synthesis of prostaglandin E 2 [WatanabeTomita et al, 1997].…”

Section: Purinergic Receptors On Osteoblastsmentioning

confidence: 99%

P2 purinergic receptors on osteoblasts and osteoclasts: Potential targets for drug development

Dixon

Sims

2000

Drug Dev. Res.

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Prostaglandin E₂is a Potential Mediator of Extracellular ATP Action in Osteoblast-Like Cells

Cited by 24 publications

References 18 publications

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

The role of purinergic signalling in the musculoskeletal system

P2 purinergic receptors on osteoblasts and osteoclasts: Potential targets for drug development

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Prostaglandin E2is a Potential Mediator of Extracellular ATP Action in Osteoblast-Like Cells

Cited by 24 publications

References 18 publications

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

Extracellular ATP and other nucleotides—ubiquitous triggers of intercellular messenger release

The role of purinergic signalling in the musculoskeletal system

P2 purinergic receptors on osteoblasts and osteoclasts: Potential targets for drug development

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Product

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Prostaglandin E₂is a Potential Mediator of Extracellular ATP Action in Osteoblast-Like Cells