Prostaglandin-dependent osmotic water permeability of the frog and trout urinary bladder

IuV, Natochin; Ei, Shakhmatova; Komissarchik, Ya. Yu.; Snigirevskaya, E. S.; Np, Prutskova; Brudnaya, M.S.

doi:10.1016/s1095-6433(98)10101-0

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…In several studies using mice and rats, it was shown that in acute water loading the animals exhibited a marked increase in urinary PGE 2 excretion . It has also been demonstrated that in osmoregulatory epithelium (skin, urinary bladder and colon), PGE 2 antagonizes AVP and promotes recovery of water impermeability . In the present study, we also demonstrated an increase of urinary PGE 2 excretion in rats following water loading.…”

Section: Discussionsupporting

confidence: 82%

Physiological mechanisms for the increase in renal solute‐free water clearance by a glucagon‐like peptide‐1 mimetic

Kutina

Marina

et al. 2013

Clin Exp Pharma Physio

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SUMMARY1. The aim of the present study was to clarify the mechanisms mediating the effect of a glucagon-like peptide-1 (GLP-1) mimetic on solute-free water excretion in rats.2. The GLP-1 mimetic exenatide (0.05-5.0 nmol/kg, i.m.), alone and in combination with either a vasopressin V 2 receptor antagonist (15 nmol/kg, i.p.) or vasopressin (0.01 nmol/kg, i.m.), was injected into control and water-loaded (water 10-50 mL/kg, p.o., or 50 mL/kg of 0.6% NaCl, i.p.) rats to evaluate the role of collecting duct water permeability in the hydrouretic effect. Urinary prostaglandin (PG) E 2 excretion and the effects of diclofenac (5 mg/kg, i.m.) and GLP-1 receptor antagonist (0.15 lmol/kg, i.p.) on exenatide action were assessed.3. The hydrouretic effect of exenatide was equivalent following oral or intraperitoneal water loading, and was proportional to the volume of water administered. Injection of exenatide, under conditions of a maximal decrease in collecting duct water permeability (V 2 receptor antagonist administration in waterloaded rats), additionally stimulated solute-free water formation. The GLP-1 receptor antagonist weakened the hydrouretic action of exenatide. Urinary PGE 2 excretion increased following water loading (47 AE 6 vs 24 AE 4 ng/kg over a 30 min period) and was enhanced as a result of additional exenatide injection (69 AE 10 ng/kg). Diclofenac and vasopressin delayed the hydrouretic effect of exenatide.4. The effect of exenatide on solute-free water clearance in water-loaded rats is presumably mediated by stimulation of PGE 2 secretion and reinforcement of tubular fluid influx from the proximal tubule to the distal segment of the nephron and collecting duct.

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Section: Discussionsupporting

confidence: 82%

Physiological mechanisms for the increase in renal solute‐free water clearance by a glucagon‐like peptide‐1 mimetic

Kutina

Marina

et al. 2013

Clin Exp Pharma Physio

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“…Presumably, efficient repairs of membrane damages limit the time and range of reaction to osmotic stress to local tissues or, in combination with modifications of signalling pathways, effectively limit the level of stress. Additionally, fatty acids are involved in the synthesis of eicosanoids 48 which, like prostaglandins, affect osmotic water permeability in trout ( Salmo trutta ) and frogs ( Rana temporaria ) 49 .…”

Section: Discussionmentioning

confidence: 99%

Alternatively spliced variants in Atlantic cod (Gadus morhua) support response to variable salinity environment

Kijewska

Malachowicz

Wenne

2018

Sci Rep

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Analysis of gill transcriptome of the Atlantic cod from the Baltic Sea demonstrated that alternatively spliced (AS) variants may be actively involved in the process of adaptation to altered salinity. Some AS variants of different genes, like phospholipase A2 group IVC (PLA2G4C), appeared only in fish exposed to altered salinity, while other isoforms of the same genes were present in all experimental groups. Novel sequence arrangements represent 89% of all AS in the Baltic cod compared to the Atlantic population. Profiles of modified pathways suggest that regulation by AS can afford specific changes of genes expressed in response to the environment. The AS variants appear to be involved in the response to stress by modifications of signalling in apoptosis pathways, an innate immunological response and pro-inflammatory process. Present results support the hypothesis that developing new AS variants could support genome complexity and reinforce the ability to fast adapt to local environments.

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“…Decreases in prostaglandin E2 (PGE2) activity are associated with increased water permeability in trout and frog urinary bladders (Parnova et al, 1997;Natochin et al, 1998). PGE2 is enzymatically converted to its active form by prostaglandin E2 synthase.…”

Section: T G Evans and G N Someromentioning

confidence: 99%

A microarray-based transcriptomic time-course of hyper- and hypo-osmotic stress signaling events in the euryhaline fishGillichthys mirabilis:osmosensors to effectors

Evans

Somero

2008

Journal of Experimental Biology

101

116

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SUMMARYCells respond to changes in osmolality with compensatory adaptations that re-establish ion homeostasis and repair disturbed aspects of cell structure and function. These physiological processes are highly complex, and require the coordinated activities of osmosensing, signal transducing and effector molecules. Although the critical role of effector proteins such as Na -co-transporters during osmotic stress are well established, comparatively little information is available regarding the identity or expression of the osmosensing and signal transduction genes that may govern their activities. To better resolve this issue, a cDNA microarray consisting of 9207 cDNA clones was used to monitor gene expression changes in the gill of the euryhaline fish Gillichthys mirabilis exposed to hyper-and hypo-osmotic stress. We successfully annotated 168 transcripts differentially expressed during the first 12 h of osmotic stress exposure. Functional classifications of genes encoding these transcripts reveal that a variety of biological processes are affected. However, genes participating in cell signaling events were the dominant class of genes differentially expressed during both hyper-and hypo-osmotic stress. Many of these genes have had no previously reported role in osmotic stress adaptation. Subsequent analyses used the novel expression patterns generated in this study to place genes within the context of osmotic stress sensing, signaling and effector events. Our data indicate multiple major signaling pathways work in concert to modify diverse effectors, and that these molecules operate within a framework of regulatory proteins. Supplementary material available online at

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Prostaglandin-dependent osmotic water permeability of the frog and trout urinary bladder

Cited by 10 publications

References 22 publications

Physiological mechanisms for the increase in renal solute‐free water clearance by a glucagon‐like peptide‐1 mimetic

Physiological mechanisms for the increase in renal solute‐free water clearance by a glucagon‐like peptide‐1 mimetic

Alternatively spliced variants in Atlantic cod (Gadus morhua) support response to variable salinity environment

A microarray-based transcriptomic time-course of hyper- and hypo-osmotic stress signaling events in the euryhaline fishGillichthys mirabilis:osmosensors to effectors

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