Prostaglandin as a Mediator of Bone Resorption Induced by Experimental Tooth Movement in Rats

Yamasaki, Kenichi; Miura, Fujio; Suda, Toshio

doi:10.1177/00220345800590101301

Cited by 194 publications

(97 citation statements)

References 20 publications

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“…Thus, comparisons are difficult. Nevertheless, the exceptional effect of aluminum to stimulate bone formation without increasing resorption remains uniquely different from that of both prostaglandin E2 and fluoride (both of which enhance resorption) (29,32).…”

Section: Discussionmentioning

confidence: 99%

Induction of de novo bone formation in the beagle. A novel effect of aluminum.

Quarles

Gitelman²,

Drezner³

1988

J. Clin. Invest.

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To define the primary effects of aluminum on bone in the mammalian species, we examined the dose/time-dependent actions of aluminum in normal beagles. Administration of low dose aluminum (0.75 mg/kg) significantly elevated the serum aluminum (151.7±19.9 ,Ag/liter) compared with that in controls (4.2±1.35 ,Ag/liter) but did not alter the calcium, creatinine, or parathyroid hormone. After 8 wk of therapy, bone biopsies displayed reduced bone resorption (2.6±0.63 vs. 4.5±0.39%) and osteoblast covered bone surfaces (2.02±0.51 vs. 7.64±1.86%), which was indicative of low turnover. In contrast, prolonged treatment resulted in increased bone volume and trabecular number (38.9±1.35 vs. 25.2±2.56% and 3.56±0.23 vs. 2.88±0.11/mm) which was consistent with uncoupled bone formation.Administration of higher doses of aluminum (1.20 mg/kg) increased the serum aluminum further (1242.3±259.8 ,ug/liter) but did not affect calcium, creatinine, or parathyroid hormone. However, after 8 wk of treatment, bone biopsies displayed changes similar to those after long-term, low-dose therapy. In this regard, an increased trabecular number (3.41±0.18/mm) and bone volume (36.5±2.38%) again provided evidence of uncoupled bone formation. In contrast, in this instance poorly mineralized woven bone contributed to the enhanced bone volume. High-dose treatment for 16 wk further enhanced bone volume (50.4±4.61%) and trabecular number (3.90±0.5/mm).These observations illustrate that aluminum may stimulate uncoupled bone formation and induce a positive bone balance. This enhancement of bone histogenesis contrasts with the effects of pharmacologic agents that alter the function of existing bone remodeling units.

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Section: Discussionmentioning

confidence: 99%

Induction of de novo bone formation in the beagle. A novel effect of aluminum.

Quarles

Gitelman²,

Drezner³

1988

J. Clin. Invest.

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“…The results of this study coincide with the results of a study carried out by Spangenberg et al, who reported that psychological stress resulted in 14% weight loss in the stress group rats compared to the control group rats in 4 weeks (32). In a study the weight of the rats in the stress group was less than that in the control group (33). Other researchers have reported that psychological stress gives rise to weight loss in rats (34).…”

Section: E290mentioning

confidence: 90%

Effect of psychological stress on orthodontic tooth movement in rats

Mirzakouchaki

Firoozi²,

Shahrbaf³

2011

Med Oral

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Introduction: The purpose of this study was to investigate the effect of psychological stress on orthodontic tooth movement in Wistar rats. Materials and methods: Forty-eight female ten-week old Wistar rats with an average weight of 188 ±12 gr were selected and randomly divided into two experimental and control groups. The experimental group received crowded environment-induced and cat odour stresses 4 weeks before spring insertion. On the 29th day in both groups, maxillary incisors were moved by the insertion of springs and exactly after 7 days, 9 rats from each group and after 14 days the remaining rats were sacrificed. Then the mesioincisal distance between maxillary incisors was measured. Afterwards, histological sections were prepared to count osteoclasts under a light microscope. The data on the extent of orthodontic tooth movement and the number of osteoclasts were analyzed by independent sample t-test. Results: The results indicated that on the 7th day after spring placement the orthodontic tooth movement was significantly higher in the control group compared to the experimental group (p<0.05). The number of osteoclasts at a significance level of α=0.1 in the control group was higher compared to the experimental group. On the 14th day after spring placement, the orthodontic tooth movement in the control group was significantly higher compared to the experimental group (p<0.05). However, there were no significant differences in the number of osteoclasts between the two groups. The rats experienced weight loss in the experimental group (p<0.05). Conclusions: Psychological stress led to a decrease in orthodontic tooth movement and in the number of osteoclasts around the root in the movement direction in rats, but a decrease in osteoclast counts was not parallel with time and demonstrated a nonlinear pattern. In addition, psychological stress led to weight loss in rats.

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“…In our experiment, we moved the maxillary first molar tooth in an anterior direction (opposite to the direction of physiologic distal drift), which induced a bone remodeling pattern opposite to that observed during physiologic drift. This change probably occurs as a result of changes in the stress/strain forces on the periodontium produced by the experimental forces on the adjacent teeth (Macapanpan et al, 1954;Waldo and Rothblatt, 1954;Zaki and Van Huysen, 1963;Azuma, 1970;Lopez Otero et al, 1973;Heller and Nanda, 1979;Yamasaki et al, 1980;Lilya et al, 1984;Martinez and Johnson, 1987;Chao et al, 1988;Lee, 1990;King et al, 1991a, b;King and Keeling, 1995;Ashizawa and Sahara, 1998). This compensatory bone deposition results from enhanced differentiation of osteoblasts from precursor cells within the PDL and the alveolar bone coincident to the tensile forces during the first 4 days of tooth movement (Pavlin and Gluhak-Heinrich, 2001), the time period used in our study.…”

Section: Discussionmentioning

confidence: 99%

“…In response to these forces, bone is deposited on the alveolar wall in regions of tension, and bone resorption occurs at sites experiencing pressure forces (Macapanpan et al, 1954;Waldo and Rothblatt, 1954;Zaki and Van Huysen, 1963; Azuma, 1970;Lopez Otero et al, 1973;Heller and Nanda, 1979;Yamasaki et al, 1980;Lilya et al, 1984;Martinez and Johnson, 1987; Chao et al, 1988;Lee, 1990; King et al, 1991a, b;King and Keeling, 1995; Ashizawa and Sahara, 1998). Rat molar teeth drift in a distal direction under physiologic conditions because the alveolus maintains net bone deposition on its mesial surface and net bone resorption on its distal surface (Sicher and Weinmann, 1944).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of alveolar bone Sharpey's fibers during experimental tooth movement in the rat

Johnson

2005

Anat. Rec.

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There is little information concerning the effects of tooth movement on the relative synthesis of bone matrix and Sharpey's fiber collagenous proteins. The purpose of this study was to investigate this situation using radioautographic techniques. The maxillary first molar tooth in rats was tipped toward the midline using an appliance and the animals were injected with 3 H-proline after 3 days and sacrificed 24 hr later. Maxillae were sectioned and silver grain proportional areas (grain density/5,000 m 2 ) evaluated over Sharpey's fibers and adjacent alveolar bone matrix using computerized densitometry and histomorphometric techniques. These data were compared to a group of untreated animals by Fisher's exact test. At depository surfaces of experimental tissues, the silver grain proportional area over bone matrix was significantly greater than over Sharpey's fibers (P Ͻ 0.05) and control bone matrix (P Ͻ 0.01). The silver grain proportional area over Sharpey's fibers was not different between the groups. At resorptive surfaces, the silver grain proportional area over both bone matrix and Sharpey's fibers was significantly greater in experimental tissues compared to controls (P Ͻ 0.01). Thus, movements of adjacent teeth affect both the quantity and ratios of collagenous protein incorporation into Sharpey's fibers and adjacent alveolar bone, which is dependent on the intensity and characteristics of the force. © 2005 Wiley-Liss, Inc.Key words: Sharpey's fibers; experimental tooth movement; alveolar bone; rat Tooth movement occurs by alveolus translocation, which is a unique type of remodeling, featuring simultaneous bone formation and resorption on opposite sides of the alveolus. Taken together, these processes result in drift of the entire alveolus in parallel to tooth drift to maintain tooth support (Roberts et al., 1981) and require remodeling of the principal fibers of the periodontal ligament (PDL), alveolar bone matrix, and the embedded Sharpey's fibers.Tooth movement produces stress/strain forces within the PDL, which are transferred to the alveolus (Tanne et al., 1987;Katona et al., 1995;Middleton et al., 1996;Puente et al., 1996;Tamatsu et al., 1996) and become transduced into a cellular response within the periodontium. In response to these forces, bone is deposited on the alveolar wall in regions of tension, and bone resorption occurs at sites experiencing pressure forces (Macapanpan et al., 1954;Waldo and Rothblatt, 1954;Zaki and Van Huysen, 1963; Azuma, 1970;Lopez Otero et al., 1973;Heller and Nanda, 1979;Yamasaki et al., 1980;Lilya et al., 1984;Martinez and Johnson, 1987; Chao et al., 1988;Lee, 1990; King et al., 1991a, b;King and Keeling, 1995; Ashizawa and Sahara, 1998). Rat molar teeth drift in a distal direction under physiologic conditions because the alveolus maintains net bone deposition on its mesial surface and net bone resorption on its distal surface (Sicher and Weinmann, 1944).

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Prostaglandin as a Mediator of Bone Resorption Induced by Experimental Tooth Movement in Rats

Cited by 194 publications

References 20 publications

Induction of de novo bone formation in the beagle. A novel effect of aluminum.

Induction of de novo bone formation in the beagle. A novel effect of aluminum.

Effect of psychological stress on orthodontic tooth movement in rats

Synthesis of alveolar bone Sharpey's fibers during experimental tooth movement in the rat

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