Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA
2
Prostanoids/TP Axis
Jiahui Ge,
Yingbi Zhou,
Hui Li
et al.
Abstract:BACKGROUND:
Prostaglandin I
2
synthesized by endothelial COX (cyclooxygenase) evokes potent vasodilation in some blood vessels but is paradoxically responsible for endothelium-dependent constriction (EDC) in others. Prostaglandin I
2
production and EDC may be enhanced in diseases such as hypertension. However, how PGIS (prostaglandin I
2
synthase) deficiency affects EDC and how this is implicated in t… Show more
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