Prostacyclin: A Solution to Some Problems of Extracorporeal Circulation

Longmore, D. B.; Gueirrara, D.; Bennett, Gregory; Smith, M.A.; Bunting, Stuart; Moncada, Salvador; Reed, Peter; Read, Nicholas G.; Vane, John R.

doi:10.1016/s0140-6736(79)92756-9

Cited by 83 publications

(14 citation statements)

References 7 publications

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“…Platelets may be consumed by adhe sion to artificial materials [29,35,36,40]. Heparin may facilitate platelet aggregation, possibly by stimulating thromboxane Aj for mation [6], ADP liberated during intravascu lar hemolysis may possibly induce some ag gregation, although ADP is rapidly broken down [11].…”

Section: Discussionmentioning

confidence: 99%

Hemostasis after Open-Heart Surgery with Extreme or Moderate Hemodilution

Dale

Lilleaasen²,

Erikssen³

1987

Eur Surg Res

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Patients who received aortic disc valves during cardiopulmonary bypass (CPB) with extreme hemodilution, obtained with preoperative blood withdrawal, infusion of acetate solution and use of blood-free priming fluid, bled less than patients operated with moderate dilution. One hour after CPB with extreme dilution when the autologous blood had been reinfused, platelet adhesiveness was twice as high as in the moderate dilution group. Other parameters of platelet function, coagulation and fibrinolysis did not differ between the groups. The higher number of reactive platelets may therefore have contributed to the improved hemostasis after extreme dilution. Later, thrombocytosis with hyperreactive platelets and hyperfïbrinogenemia developed in all patients. This might predispose for thrombosis.

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Section: Discussionmentioning

confidence: 99%

Hemostasis after Open-Heart Surgery with Extreme or Moderate Hemodilution

Dale

Lilleaasen²,

Erikssen³

1987

Eur Surg Res

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“…Infusion of prostacyclin into animals subjected to renal dialysis, 179 charcoal hemoperfusion, 180 and cardiopulmonary bypass 181 increases the biocompatibility of the procedure and reduces the requirement for heparin, thus avoiding the complications of thrombocytopenia and thromboembolic episodes that sometimes accompany the use of heparin. 182 ' 183 Prostacyclin has now been used in patients undergoing cardiopulmonary bypass, 184 " 88 charcoal hemoperfusion, 189 and hemodialysis, 190191 with the same beneficial results.…”

Section: Therapeutic Potential Of Prostacyclinmentioning

confidence: 99%

Prostacyclin and arterial wall biology.

Moncada¹

1982

Arteriosclerosis

155

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“…145 In animals subjected to experimental renal dialysis, 146 charcoal haemoperfusion 147 and cardiopulmonary bypass, 148 infusion of prostacyclin prevented this platelet damage and thrombocytopenia, thus increasing the biocompatibility of the procedure. Platelet aggregates in the blood returning to the animals, as measured by Swank screen filtration pressure, were also reduced by infusion of prostacyclin.…”

mentioning

confidence: 99%