Prospects of the Use of New Carbon Sorbents with Antimicrobial Properties in the Intensive Care Medicine

Abstract

The purpose is to study antibacterial and antimycotic properties of produced granular carbon sorbents. Material and methods. A VNIITU-1 carbon sorbent was used as a starting material, which was modified with polyvinylpyrrolidone and lactic and glycolic acids oligomers. Microbiological bench tests were carried out to determine the antibacterial and antimycotic activity of these granulated carbon hemosorbents. Antibacterial properties of sorbents were studied in relation to pathogenic and conditionally pathogenic microorganisms: Staphylococcus aureus, Pseudomonas aeroginosa, Klebsiella pneumonia, Escherichia coli, Streptococcus agalactiae as well as their mixtures: mixture No. 1 — S. aureus and E. coli; mixture No. 2 — S. aureus and P. aeruginosa. Results. Presented data demonstrate that the modified VNIITU-1 exhibits significant antibacterial and antimycotic activity against most of the studied microorganisms compared to original sorbent. Conclusion. Modified sorbents as antimicrobial and detoxifying drugs may further be employed in treatment of obstetrical-gynecological and surgical diseases. The carbon sorbents are promising materials for medicine, as they expand the potential of sorption therapy in clinical practice.

Applicability of modified carbon sorbent for removing potentially toxic biologically active molecules of aromatic structure from blood plasma

“…At this stage of the work, the study of the interaction of the sorbent and PhPA by physico-chemical methods was not carried out in sufficient detail. In connection with the results obtained in previous works, 24,32 physical sorption of PhPA is possible due to the commensurability of the sizes of the mesopores of the carbon sorbent and the size of the PhPA molecule. The sorbent pore diameter is 50-60 nm 22 and significantly exceeds the diameter of the PhPA molecule, equal to 0.6-0.8 nm.…”

“…These sorbents are capable of inactivating the waste products from the body, including toxic metabolites. 24 In this work, a mesoporous carbon sorbent VNIITU-2 modified with 3-phenylpropionic acid has been developed to create preparations of complex prolonged action possessing antibacterial properties due to the applied modifier exhibiting its own biospecific properties.…”