Prospects of Boswellic Acids as Potential Pharmaceutics

Du, Zhiyong; Liu, Zhenli; Ning, Zhangchi; Liu, Yuanyan; Song, Zhilong; Wang, Chun; Lü, Aiping

doi:10.1055/s-0034-1396313

Cited by 71 publications

(40 citation statements)

References 90 publications

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“…Furthermore, AKBA failed to inhibit 5-LO product formation in human whole blood, showing activity only in enzyme assays [19]. In addition, recent research revealed little relevance for 5-LO in the inflammatory response associated with osteoarthritis, the major clinical indication of Boswellia extracts [20,21]. All products included in this survey are sold as botanical dietary supplements and are not intended to diagnose, treat, cure, or prevent any disease.…”

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confidence: 97%

Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids

et al. 2016

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Introduction !With millions of people using medicinal plants worldwide, the market of herbal supplements is witnessing a steady growth. Recent data indicate that in 2012, 17.9 % of all US adults used botanical supplements [1]. In Germany, 90 % of the people use natural medicines at some time during their life and over 50 % of the population has done so in other European countries [2,3]. Thus, the globAbstract !

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confidence: 97%

Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids

et al. 2016

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“…[143]. Moreover, the reputation of BAs as potential pharmaceutical candidates found support in numerous studies [145]. A search in the frame of the EC-funded PlantLIBRA project retrieved six human studies reporting positive effects of B. serrata on several biomarkers such as nitric oxide, malondialdehyde, leukotriene C4, metalloprotease-3, eosinophil counts, leucocyte infiltration, etc.…”

Section: Exemplary Herbs Of Encouraging Benefitsmentioning

confidence: 99%

Do We Need Plant Food Supplements? A Critical Examination of Quality, Safety, Efficacy, and Necessity for a New Regulatory Framework

Abdel‐Tawab

2017

Planta Med

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Given the expanding market of plant food supplements (PFSs) not undergoing any pre-marketing authorization, the overall quality, safety and efficacy of PFSs were subjected to a critical examination. Although many high-quality PFSs exist on the legal market, quality concerns are in general justified. Besides economic adulteration, active ingredients dramatically differing from label claims and among products were reported in several studies. In addition, PFSs sold via the Internet may be intentionally adulterated with undeclared prescription drugs. Compared to PFSs with only one single herb, PFSs containing herbal mixtures were more involved in moderate and severe clinical courses. Although prohibited by regulation, misleading labels on PFSs are common. Above all, only vague evidence for the efficacy of PFSs exists. Notwithstanding the unproven efficacy and insufficient safety assessment, PFSs represent a relevant source for consumers to get access to herbal preparations in the United States and meanwhile also in Europe, as launching of licensed/registered European herbal medicinal products (HMPs) has steadily decreased. However, being non-vitamin, non-mineral products, PFSs are neither food nor drugs. In terms of protecting public health and providing the consumer with high-quality, effective, and safe PFSs, possibilities are shown how to deal with the many challenges of PFSs. Last but not least, suggestions are made for assigning PFSs a separate regulatory category being less regulated compared to HMPs but more strictly regulated compared to food laws including implementation of good manufacturing practices and a scientific pre-marketing review process by an expert commission.

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“…Their common medicinal properties are recognized in the treatment of inflammatory conditions, some cancerous diseases, and wound healing in the traditional medicines of India, China, Rome, Greece, Babylon, and elsewhere 3 . In the course of our characterization studies of the anti-inflammatory constituents in the gum resins of frankincense and myrrh, several terpenoid constituents were found to inhibit nitric oxide production in lipopolysaccharide LPS -activated mouse peritoneal boswellic acids; BAs 28 , and cembrane-type diterpenes, incensol and related compounds incensols: ICs 6, 15, 25 , have been identified as major constituents and have been considered to be biomarkers of frankincense Fig. 1 .…”

Section: Introductionmentioning

confidence: 99%

A Review of Anti-inflammatory Terpenoids from the Incense Gum Resins Frankincense and Myrrh

2017

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Prospects of Boswellic Acids as Potential Pharmaceutics

Abstract: Boswellia serrata l " Burseraceae l " boswellic acids l " derivatization l " pharmacokinetics l " analysis methods l " new formula

Cited by 71 publications

References 90 publications

Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids

Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids

Do We Need Plant Food Supplements? A Critical Examination of Quality, Safety, Efficacy, and Necessity for a New Regulatory Framework

A Review of Anti-inflammatory Terpenoids from the Incense Gum Resins Frankincense and Myrrh

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