Timeliness of the problem being studied is determined by a necessity to form general cultural competences of students of institutions of higher technical education, as changes in society, social and economic life of the country lead to shifting the values and, simultaneously, to decrease in the cultural level of people. The paper is aimed as looking for new ways within the educational system of the institution of higher technical education, directed towards humanization and humanitarization of higher education that is to facilitate development of general cultural competences and optimization of the higher technical education as a whole. The leading method of study of this problem is a pedagogical experiment that allows for revealing as well as giving theoretic justification and experimental confirmation of the maturity level of the general cultural competences of technical students during the learning process. The research sees the interdisciplinary approach as an important pedagogical subsystem of the learning process, built with considerations for its essential characteristics on the foundation of competency-building and student-centered approaches; at that, some pedagogical conditions are implemented in the form of intersubjective relationships being built between an instructor and their students. The scientific and methodological material presented in the paper and used during binary lectures and practical sessions facilitate development of the general cultural competences during theoretical studies.