Prospects of application of melanins as antiaging agents in elastomer compositions

Каблов, В. Ф.; Novopoltseva, Oksana M.; Gracheva, N. V.; Zheltobryukho, Victor F.; Dao, Pham Kim

doi:10.1002/vjch.201960024

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…Due to the unique features of melanin that were revealed by studies of animal, fungal and synthetic melanins, perspectives to use it in a broad range of biomedical and technological applications has been demonstrated ( d’Ischia et al, 2015 ; Di Mauro et al, 2017 ; Vahidzadeh et al, 2018 ). Recently sunflower husks melanin was successfully used as a sorbent with high enterosorption efficiency and as an antiaging agent in elastomer compositions ( Gracheva and Zheltobryukhov, 2019 ; Kablov et al, 2019 ). Besides technological application, melanin is considered as a food supplement that can increase nutrition value of stable food, for example, the melanin isolated from black garlic ( Wang and Rhim, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Features of Activity of the Phenylpropanoid Biosynthesis Pathway in Melanin-Accumulating Barley Grains

et al. 2022

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Barley (Hordeum vulgare L.) grain pigmentation is caused by two types of phenolic compounds: anthocyanins (which are flavonoids) give a blue or purple color, and melanins (which are products of enzymatic oxidation and polymerization of phenolic compounds) give a black or brown color. Genes Ant1 and Ant2 determine the synthesis of purple anthocyanins in the grain pericarp, whereas melanins are formed under the control of the Blp1 gene in hulls and pericarp tissues. Unlike anthocyanin synthesis, melanin synthesis is poorly understood. The objective of the current work was to reveal features of the phenylpropanoid biosynthesis pathway functioning in melanin-accumulating barley grains. For this purpose, comparative transcriptomic and metabolomic analyses of three barley near-isogenic lines accumulating anthocyanins, melanins, or both in the grain, were performed. A comparative analysis of mRNA libraries constructed for three stages of spike development (booting, late milk, and early dough) showed transcriptional activation of genes encoding enzymes of the general phenylpropanoid pathway in all the lines regardless of pigmentation; however, as the spike matured, unique transcriptomic patterns associated with melanin and anthocyanin synthesis stood out. Secondary activation of transcription of the genes encoding enzymes of the general phenylpropanoid pathway together with genes of monolignol synthesis was revealed in the line accumulating only melanin. This pattern differs from the one observed in the anthocyanin-accumulating lines, where — together with the genes of general phenylpropanoid and monolignol synthesis pathways — flavonoid biosynthesis genes were found to be upregulated, with earlier activation of these genes in the line accumulating both types of pigments. These transcriptomic shifts may underlie the observed differences in concentrations of phenylpropanoid metabolites analyzed in the grain at a late developmental stage by high-performance liquid chromatography. Both melanin-accumulating lines showed an increased total level of benzoic acids. By contrast, anthocyanin-accumulating lines showed higher concentrations of flavonoids and p-coumaric and ferulic acids. A possible negative effect of melanogenesis on the total flavonoid content and a positive influence on the anthocyanin content were noted in the line accumulating both types of pigments. As a conclusion, redirection of metabolic fluxes in the phenylpropanoid biosynthesis pathway occurs when melanin is synthesized.

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Section: Introductionmentioning

confidence: 99%

Features of Activity of the Phenylpropanoid Biosynthesis Pathway in Melanin-Accumulating Barley Grains

et al. 2022

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“…Since plant melanin is present in most cases in low-cost agricultural waste products (e.g., grape pomace and sunflower seed husks), it has attracted special attention. The potential of melanin from sunflower husks as a sorbent with high enterosorption efficiency and as an antiaging agent in elastomer compositions has been demonstrated (Gracheva and Zheltobryukhov, 2019;Kablov et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Melanin Pigment in Plants: Current Knowledge and Future Perspectives

2020

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The word "melanin" refers to a group of high molecular weight, black, and brown pigments formed through the oxidation and polymerization of phenolic compounds. This pigment is present in all kingdoms of living organisms, but it remains the most enigmatic pigment in plants. The poor solubility of melanin in particular solvents and its complex polymeric nature significantly constrain its study. Plant melanin synthesis is mostly associated with the enzymatic browning reaction that occurs in wounded plant tissues. This reaction occurs when, due to the disruption of cellular compartmentation, the chloroplast-located polyphenol oxidases (PPOs) release from the chloroplast and interact with their vacuolar substrates to produce o-quinones, which in turn polymerize to melanin. Furthermore, the presence of melanin in intact seed tissues has been demonstrated by diagnostic physicochemical tests. Unlike the well-studied enzymatic browning reaction, little is known about how melanin is formed in seeds. Recent data have shown that it is a tightly controlled genetic process that involves many genes, among which the genes encoding PPOs might be key. The present article aims to provide an overview of the current knowledge on melanin in plants and to discuss future perspectives on its study in light of recent findings.

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“…Allomelanin is a dark, insoluble pigment that leads to brown and black seed color in plants. Despite its biomedical and technological applications as a unique material, natural melanin also has a wide range of biological activities and human health benefits, such as antioxidant, antimicrobial, anti-HIV, anticancer, anti-inflammatory, immunomodulatory, and anti-aging effects [14][15][16][17]. However, the biochemical and genetic aspects of melanin formation in plants have not been extensively studied because of the complex polymeric nature of melanin and the interference of other pigments.…”

Section: Introductionmentioning

confidence: 99%

Conjunctive Analyses of BSA-Seq and BSR-Seq to Identify Candidate Genes Controlling the Black Lemma and Pericarp Trait in Barley

Liu

Chen

et al. 2023

IJMS

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Black barley seeds are a health-beneficial diet resource because of their special chemical composition and antioxidant properties. The black lemma and pericarp (BLP) locus was mapped in a genetic interval of 0.807 Mb on chromosome 1H, but its genetic basis remains unknown. In this study, targeted metabolomics and conjunctive analyses of BSA-seq and BSR-seq were used to identify candidate genes of BLP and the precursors of black pigments. The results revealed that five candidate genes, purple acid phosphatase, 3-ketoacyl-CoA synthase 11, coiled-coil domain-containing protein 167, subtilisin-like protease, and caffeic acid-O-methyltransferase, of the BLP locus were identified in the 10.12 Mb location region on the 1H chromosome after differential expression analysis, and 17 differential metabolites, including the precursor and repeating unit of allomelanin, were accumulated in the late mike stage of black barley. Phenol nitrogen-free precursors such as catechol (protocatechuic aldehyde) or catecholic acids (caffeic, protocatechuic, and gallic acids) may promote black pigmentation. BLP can manipulate the accumulation of benzoic acid derivatives (salicylic acid, 2,4-dihydroxybenzoic acid, gallic acid, gentisic acid, protocatechuic acid, syringic acid, vanillic acid, protocatechuic aldehyde, and syringaldehyde) through the shikimate/chorismite pathway other than the phenylalanine pathway and alter the metabolism of the phenylpropanoid-monolignol branch. Collectively, it is reasonable to infer that black pigmentation in barley is due to allomelanin biosynthesis in the lemma and pericarp, and BLP regulates melanogenesis by manipulating the biosynthesis of its precursors.

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Prospects of application of melanins as antiaging agents in elastomer compositions

Cited by 6 publications

References 3 publications

Features of Activity of the Phenylpropanoid Biosynthesis Pathway in Melanin-Accumulating Barley Grains

Features of Activity of the Phenylpropanoid Biosynthesis Pathway in Melanin-Accumulating Barley Grains

Melanin Pigment in Plants: Current Knowledge and Future Perspectives

Conjunctive Analyses of BSA-Seq and BSR-Seq to Identify Candidate Genes Controlling the Black Lemma and Pericarp Trait in Barley

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