Prospects of application of acetyl-L-carnitine in neurology and psychiatry (the treatment of polyneuropathy and depressive states)

Anikin, G S; Makhova, A.A.; Ших, Е. В.

doi:10.17116/jnevro2019119081130

Cited by 2 publications

(2 citation statements)

References 21 publications

(18 reference statements)

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“…ALC exhibits a variety of physiological activities, including nutritional effects, neuroprotective effects, analgesic effects of the peripheral nervous system, antioxidant effects, and plays important roles in the functioning of male reproductive system. Commercially, ALC‐based drugs are mainly used to improve male fertility, treat Alzheimer’s disease, hepatic encephalopathy, depression, and diabetic peripheral neuropathy (Anikin, Makhova, & Shikh, 2019; Di Stefano, Di Lionardo, Galosi, Truini, & Cruccu, 2019; Gamidov, Ovchinnikov, & Popova, 2019; Jeong et al, 2017; Ponomareva, 2017; Rolim, da Silva, Flumignan, Abreu, & Dib, 2019).…”

Section: Introductionmentioning

confidence: 99%

A UPLC–MS/MS method for determination of endogenous l‐carnitine and acetyl‐l‐carnitine in serum of patients with depression

Nie

Liang

Shan

et al. 2020

Biomedical Chromatography

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A simple, rapid, and selective ultra‐performance liquid chromatography–tandem mass spectrometry method for determination of l‐carnitine (LC) and acetyl‐l‐carnitine (ALC) in human serum was developed. Acetyl‐l‐carnitine‐d3 (ALC‐d3) was selected as internal standard (IS). After protein precipitation with acetonitrile–water (1 mL, 2:1, v/v), the analytes and IS were separated on a 2.5‐μm XSelect HSS T3 C18 column by gradient elution with methanol–water (containing 0.01% ammonia water) as the mobile phase at a flow rate of 0.2 mL/min. Analytes were detected with multiple reaction monitoring using a positive scan mode with electrospray ionization. Good linearity (R2 > 0.999) was observed in the concentration range for LC and ALC. The inter‐ and intra‐day values of relative error were −10.4% to 10.0% with CVs less than 9.84%. The average recoveries of the two analytes were 91.29%–98.23%. Blood samples containing LC and ALC were stable under various storage conditions. Normal, haemolytic, and hyperlipidaemic serum had no significant effect on the quantification of LC and ALC. This method was successfully applied to study the concentrations of endogenous LC and ALC in the serum of patients with first‐episode depression.

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Section: Introductionmentioning

confidence: 99%

A UPLC–MS/MS method for determination of endogenous l‐carnitine and acetyl‐l‐carnitine in serum of patients with depression

Nie

Liang

Shan

et al. 2020

Biomedical Chromatography

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“…Studies have shown that abortion can cause varying degrees of physical and mental harm to women, and in some cases, may lead to death [3]. The mental state of women with induced elective termination of pregnancy is often related to various postoperative diseases, especially postoperative depression [4]. Depression, a mental disorder characterized by persistently depressed mood, is a common disease that endangers human physical and mental health.…”

Section: Introductionmentioning

confidence: 99%

High-Risk Factors for Depression in Women before Performing an Elective Termination of Pregnancy: A Prospective Study

Li¹,

Zhang²,

Zhang³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: As the phenomenon becomes increasingly prominent, the medical community is paying more and more attention to the health of women with elective termination of pregnancy. This study investigated the incidence of preoperative pre-abortion and its highrisk factors in elective termination of pregnancy women. Health interventions were used to reduce the incidence of such pre-abortion, and targeted to the post-abortion care. Methods: Using a convenient sampling method, 170 women who elected to terminate pregnancy in the gynecological clinic of Beijing Ditan Hospital from 1 June 2019 to 1 June 2020 were selected. A questionnaire in two parts was used as a research tool. General information collected mainly included the presence or absence of sexually transmitted diseases, age, address, education, economic level, occupation, etc., as well as the self-measurement Self-rating Depression Scale (SDS) for pre-abortion. Results:The average SDS score of 170 women who have elective termination of pregnancy was 51.2 ± 11.7. With a SDS score ≥53 points in 75 patients, the incidence of depression was 44.1% (75/170). Factors associated with depression were patient age (p = 0.002), education level (p = 0.040), and the man's refusal for use of contraception during sexual intercourse (p = 0.000). Conclusions: Our research suggests that younger age, lower education, and inactive use of male contraception during sex are risk factors for pre-abortion in women with abortion. Physicians should consider these findings for early detection of pre-abortion and timely intervention for such women.

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Prospects of application of acetyl-L-carnitine in neurology and psychiatry (the treatment of polyneuropathy and depressive states)

Cited by 2 publications

References 21 publications

A UPLC–MS/MS method for determination of endogenous l‐carnitine and acetyl‐l‐carnitine in serum of patients with depression

A UPLC–MS/MS method for determination of endogenous l‐carnitine and acetyl‐l‐carnitine in serum of patients with depression

High-Risk Factors for Depression in Women before Performing an Elective Termination of Pregnancy: A Prospective Study

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