Prospects of Apoptotic Cell-Based Therapies for Transplantation and Inflammatory Diseases

Saas, Philippe; Kaminski, Sandra; Perruche, Sylvain

doi:10.2217/imt.13.103

Cited by 33 publications

(34 citation statements)

References 160 publications

(280 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However confirmation of this theory has been hampered by the difficulty in tracking the fate of engulfed endogenous apoptotic cells. Nonetheless, there is abundant evidence that apoptotic cells can suppress macrophage inflammatory responses in vitro and that failure to clear apoptotic cells exacerbates inflammation in vivo, indicating efferocytosis plays a crucial role in modulating the inflammatory response of macrophages (and other phagocytes) to promote resolution (5, 6, 22). …”

Section: Introductionmentioning

confidence: 99%

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

Elliott

Koster

Murphy

2017

The Journal of Immunology

323

274

View full text Add to dashboard Cite

Since the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the phagocytic clearance of cellular debris has been considered an integral component of resolving inflammation and restoring function of damaged and infected tissues. We now know that the phagocytic clearance of dying cells (efferocytosis), particularly by macrophages and other immune phagocytes, has profound consequences on innate and adaptive immune responses in inflamed tissues. These immunomodulatory effects result from an array of molecular signaling events between macrophages, dying cells and other tissue-resident cells. In recent years, many of these molecular pathways have been identified and studied in the context of tissue inflammation, helping us better understand the relationship between efferocytosis and inflammation. We review specific types of efferocytosis-related signals that can impact macrophage immune responses and discuss their relevance to inflammation-related diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

Elliott

Koster

Murphy

2017

The Journal of Immunology

323

274

View full text Add to dashboard Cite

show abstract

“…Moreover, aberrant interstitial cell clearance is increasingly being viewed as both a cause and consequence of the pathobiology of many diseases (Elliott and Ravichandran, 2010; Green et al, 2016; S. Nagata et al, 2010; Poon et al, 2014b; Saas et al, 2013). Accordingly, there is growing interest in understanding the regulatory networks that control this dynamic and ubiquitous biophysical process.…”

Section: Introductionmentioning

confidence: 99%

The Dynamics of Apoptotic Cell Clearance

2016

View full text Add to dashboard Cite

Summary The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.

show abstract

“…Currently, apoptotic cells are used for various forms of therapy, especially with the objective of promoting immunological tolerance in recipient individuals [82]. Therefore, stabilization of apoptotic cells before their administration to patients may ensure that apoptotic cells will retain their characteristic features until they are removed by macrophages.…”

Section: Zombie Cells: Stabilization Of Apoptotic Cellsmentioning

confidence: 99%

Cytoskeleton Rearrangements during the Execution Phase of Apoptosis

Doncel¹,

Ojeda²,

Oropesa-Ávila³

et al. 2017

Cytoskeleton - Structure, Dynamics, Function and Disease

View full text Add to dashboard Cite

Apoptosis is a regulated energy-dependent process for the elimination of unnecessary or damaged cells during embryonic development, tissue homeostasis and many pathological conditions. Apoptosis is characterized by specific morphological and biochemical features in which caspase activation has a pivotal role. During apoptosis, cells undergo characteristic morphological reorganizations in which the cytoskeleton participates actively. Traditionally, this cytoskeleton rearrangement has been assigned mainly to actinomyosin ring contraction, with microtubule and intermediate filaments both reported to be depolymerized at early stages of apoptosis. However, recent results have shown that microtubules are reformed during the execution phase of apoptosis forming an apoptotic microtubule network (AMN). Current hypothesis proposes that AMN is required to maintain plasma membrane integrity and cell morphology during the execution phase of apoptosis. AMN disruption provokes apoptotic cell collapse, secondary necrosis and the subsequent release of toxic molecules which can damage surrounding cells and promote inflammation. Therefore, AMN formation in physiological or pathological apoptosis is essential for tissue homeostasis.

show abstract

Prospects of Apoptotic Cell-Based Therapies for Transplantation and Inflammatory Diseases

Cited by 33 publications

References 160 publications

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

The Dynamics of Apoptotic Cell Clearance

Cytoskeleton Rearrangements during the Execution Phase of Apoptosis

Contact Info

Product

Resources

About