Prospects for worldwide tuberculosis control under the WHO DOTS strategy

Dye, Christopher; Garnett, Geoffrey P.; Sleeman, Karen; Williams, Brian G.

doi:10.1016/s0140-6736(98)03199-7

Cited by 389 publications

(326 citation statements)

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“…Dye et al predicted that in settings with no HIV, reaching the WHO targets for DOTS would result in an annual decrease of > 7% in TB reporting rates ( 8 ). However, correction for HIV only resulted in a small (0.3%) decline, showing that direct effect of HIV provides only partial explanation for the observed lack of effect of DOTS in Ho Chi Minh City.…”

Section: Discussionmentioning

confidence: 99%

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HIV and Tuberculosis in Ho Chi Minh City, Vietnam, 1997–2002

Tran

Houben

Hoang

et al. 2007

Emerg. Infect. Dis.

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Section: Discussionmentioning

confidence: 99%

“…As a result, TB incidence was expected to decline ( 8 ), but thus far this has not happened ( 9 ). One possible explanation for this phenomenon is HIV infection.…”

mentioning

confidence: 99%

HIV and Tuberculosis in Ho Chi Minh City, Vietnam, 1997–2002

Tran

Houben

Hoang

et al. 2007

Emerg. Infect. Dis.

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“…Figure 1a depicts the simplest, and most commonly used [23][24][25] , conceptualization of TB diagnosis in mathematical models so far. In this framework, on becoming infectious, people with TB experience a series of uniform processes.…”

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confidence: 99%

Understanding the incremental value of novel diagnostic tests for tuberculosis

Arinaminpathy

Dowdy

2015

Nature

109

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Tuberculosis is a major source of global mortality caused by infection, partly because of a tremendous ongoing burden of undiagnosed disease. Improved diagnostic technology may play an increasingly crucial part in global efforts to end tuberculosis, but the ability of diagnostic tests to curb tuberculosis transmission is dependent on multiple factors, including the time taken by a patient to seek health care, the patient's symptoms, and the patterns of transmission before diagnosis. Novel diagnostic assays for tuberculosis have conventionally been evaluated on the basis of characteristics such as sensitivity and specificity, using assumptions that probably overestimate the impact of diagnostic tests on transmission. We argue for a shift in focus to the evaluation of such tests' incremental value, defining outcomes that reflect each test's purpose (for example, transmissions averted) and comparing systems with the test against those without, in terms of those outcomes. Incremental value can also be measured in units of outcome per incremental unit of resource (for example, money or human capacity). Using a novel, simplified model of tuberculosis transmission that addresses some of the limitations of earlier tuberculosis diagnostic models, we demonstrate that the incremental value of any novel test depends not just on its accuracy, but also on elements such as patient behaviour, tuberculosis natural history and health systems. By integrating these factors into a single unified framework, we advance an approach to the evaluation of new diagnostic tests for tuberculosis that considers the incremental value at the population level and demonstrates how additional data could inform more-effective implementation of tuberculosis diagnostic tests under various conditions

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“…44. Achieving these targets reduces the transmission of TB and, in the absence of HIV, incidence falls 45 . Initially, resources were limited and priority was given to the infectious, smear-positive cases that were likely to spread disease.…”

Section: Strategies Available To Control Tbmentioning

confidence: 99%

Tuberculosis control in the era of HIV

et al. 2005

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| Without HIV, the tuberculosis (TB) epidemic would now be in decline almost everywhere. However, instead of looking forward to the demise of TB, countries that are badly affected by HIV are struggling against a rising tide of HIV-infected patients with TB. As a consequence, global TB control policies have had to be revised and control of TB now demands increased investment. This paper assesses what is being done to address the issue and what remains to be done.

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Prospects for worldwide tuberculosis control under the WHO DOTS strategy

Cited by 389 publications

References 8 publications

HIV and Tuberculosis in Ho Chi Minh City, Vietnam, 1997–2002

HIV and Tuberculosis in Ho Chi Minh City, Vietnam, 1997–2002

Understanding the incremental value of novel diagnostic tests for tuberculosis

Tuberculosis control in the era of HIV

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