Prospects for vaccines against rotaviruses

Desselberger, Ulrich

doi:10.1002/(sici)1099-1654(199801/03)8:1<43::aid-rmv206>3.3.co;2-f

Cited by 2 publications

(2 citation statements)

References 63 publications

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“…Change in rotavirus G-type prevalence over time has been well recognized [Bishop et al, 1991;Nakata et al, 1999]. Genetic drifts, caused by accumulation of point mutations, and genetic shifts, caused by reassortment of different rotaviruses, could result in evolution of the virus [Desselberger, 1998]. The frequency of untypable strains was 24/747 (3.2%) in the current study, which was comparable with the range of 2-56.7% reported from Asian countries [Song et al, 2003].…”

Section: Discussionsupporting

confidence: 79%

Changing epidemiology of rotavirus G‐types circulating in Hong Kong, China

Lo¹,

Szeto²,

Tsang³

et al. 2004

Journal of Medical Virology

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Group A rotaviruses are the most common cause of severe diarrhoeal disease in young children worldwide. The development of a vaccine is advocated by the World Health Organization. Obtaining local baseline information regarding rotavirus strain variation is important to ensure matching of circulating and vaccine strains. The current study was undertaken to determine the epidemiology of rotavirus G-types in Hong Kong in anticipation of a vaccination program. From 2001 to 2002 over a period of one year, diarrhoeal stool specimens known to be positive for rotavirus were subjected to G-typing by reverse transcriptase-polymerase chain reaction using nested type-specific primers. Rotavirus G-type distribution was correlated with patient demographics. Among 747 rotavirus positive stool specimens, 723 strains could be G-typed as G1 (302, 40.4%), G2 (128, 17.1%), G3 (231, 30.9%), G4 (24, 3.2%), and G9 (38, 5.1%). G1 strains were found predominantly in those 5 years old or younger (P < 0.0001), while G2 strains were more prevalent among those over 5 years of age (P < 0.001). When compared with similar studies in 1983 to 1984 and 1999 to 2000, there were significant changes in the prevalence of various G-types, with consistent detection of G9 strains in the current study. It is concluded that rotavirus G-type distribution in Hong Kong has varied with time. Continuous monitoring of the epidemiology of rotavirus is important, especially in anticipation of the introduction of a vaccine, in order to document its impact and to ensure its continued effectiveness.

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Section: Discussionsupporting

confidence: 79%

Changing epidemiology of rotavirus G‐types circulating in Hong Kong, China

Lo¹,

Szeto²,

Tsang³

et al. 2004

Journal of Medical Virology

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show abstract

“…The function of these IgAs is in bacterial neutralization, viral neutralization or antibody-dependent cytotoxicity (ADCC). IgA may also be involved in intracellular "neutralization" (Burns et al, 1996;Desselberger, 1998). In rotavirus infections copro-IgAs were found to be the best correlate of protection (Coulson et al, 1992;Feng et al, 1994;Burns et al, 1996;Feng et al, 1997).…”

Section: Immunologymentioning

confidence: 99%

Viral gastroenteritis: Causes, pathophysiology, immunology, treatment, and epidemiology

2003

Perspectives in Medical Virology

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Prospects for vaccines against rotaviruses

Cited by 2 publications

References 63 publications

Changing epidemiology of rotavirus G‐types circulating in Hong Kong, China

Changing epidemiology of rotavirus G‐types circulating in Hong Kong, China

Viral gastroenteritis: Causes, pathophysiology, immunology, treatment, and epidemiology

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