Prospects for using Origanum Syriacum (L.) as a source of antimicrobial agents

Abstract

Origanum syriacum ( O. syriacum ) (L.) belongs to Group B of the genus Origanum from ( Lamiaceae ), which is rich in essential oils that exhibit antimicrobial efficacy, anti-inflammatory efficacy, antioxidant activity, and antitumor efficacy. These processing activities are because of its richness in carvacrol and Thymol. In this article, we will focus on O. syriacum , discussing the antimicrobial efficacy for its essential oil and extracts, in addition, cast light on mechanism of essential oil antimicrobial action. This study was conducted from March 2019 to February 2021. We have analyzed the results of studies on antimicrobial efficacy of a plant O. syriacum in the PubMed, Google Scholar, Elsevier over the past 15 years using keywords. O. syriacum essential oil and its extracts have an extensive antimicrobial efficacy give it a great importance in pharmaceutical and medical purposes.

Antibacterial and Antifungal Activities of Cimbopogon winterianus and Origanum syriacum Extracts and Essential Oils against Uropathogenic Bacteria and Foodborne Fungal Isolates

“…Carvacrol was proved to be the most effective component against microbes. Thymol and carvacrol were proved to exert toxic effects, especially against E. coli and S. aureus , with a stronger action by carvacrol [ 14 ].…”

“…In addition, these bactericidal and bacteriostatic activities could be due to the hydrophobic nature of the extracts and EOs, which facilitate their penetration into the bacterial cell, thus changing the orientation of lipids in the cell membrane [ 14 ]. These changes alter the chemical and physical properties of the cell membrane, which increases the electron flow and proton flux across the membrane, thus coagulating the cell contents and causing cell death [ 14 , 19 ]. Among the tested bacterial isolates, S. aureus was the most sensitive bacterium and E. coli was the most resistant.…”

“…The antimicrobial effect of extracts and EOs is usually caused by phenolics and monoterpenes, especially carvacrol and thymol. Carvacrol is considered one of the most effective antimicrobials [ 14 ]. The effectiveness of O. syriacum extract against a wide spectrum of pathogenic microorganisms has been reported [ 14 , 15 ].…”

“…Carvacrol is considered one of the most effective antimicrobials [ 14 ]. The effectiveness of O. syriacum extract against a wide spectrum of pathogenic microorganisms has been reported [ 14 , 15 ]. In general, the effectiveness is linked to the high carvacrol content in the extract.…”

Сultivation experiment of Origanum vulgare L. in Northern Kazakhstan using nitrogen fertilizer

“…O. vulgare L. provides beneficial properties due to its content of thymol, carvacrol, β-caryophyllene, rosemary acid, terpenes, flavonoids, phenolic acid, as well as trace elements and vitamins (Karaoğlan et al, 2017;Mohamad et al, 2021). Carvacrol and thymol contained in the essential oil of O. vulgare L. exhibit antioxidant, antifungal and antimicrobial activity (Nostro and Papalia, 2011;Marchese et al, 2018;Soltani et al, 2021;Chun et al, 2005).…”