Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections

Юрьева, О. В.; Дубровина, В. И.; Pyatidesyatnikova, A. B.

doi:10.29413/abs.2021-6.3.6

Cited by 1 publication

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“…Кроме того, перспективным представляется использование в качестве адъювантов иммуноактиваторов на основе селенсодержащих соединений. По литературным данным известно, что селенорганические препараты обладают антиоксидантным потенциалом, иммунотропными свойствами и способны модулировать вакцинальный иммуногенез [3][4][5].…”

Section: Infectious Diseases инфекционные болезни введениеunclassified

Structural rearrangement of organs of white mice vaccinated with Yersinia pestis EV in combination with organoselenium compound 974zh

Дубровина

Starovoytova

Юрьева

et al. 2022

Acta biomedica scientifica

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Introduction. An urgent direction is the search for means that increase the effectiveness of the Y. pestis EV NIIEG vaccine and reduce the side pathological manifestations caused by it. Organoselenium compounds have immunotropic properties and increase the antioxidant potential of the body, as well as have an antidystrophic effect and an antiallergic effect. Materials of the study of the immunomodulating effect of the experimental selenium-containing compound 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonane dibromide (974zh) on the macroorganism of laboratory animals are presented.The aim. To evaluate the effect of the organoselenium compound 974zh on the structural rearrangement of the organs of experimental animals in the dynamics of the vaccine process caused by Y. pestis EV.Methods. The study was carried out on 70 certified outbred white mice. Histological material (thymus, lymph nodes, spleen, adrenal glands, liver) was embedded in paraffin, semi-thin sections were stained with hematoxylin and eosin, thionin, and by the Brachet method. The severity of pathological changes in the liver and adrenal glands, proliferation of plasma cells and structural changes in immunocompetent organs (thymus, lymph nodes and spleen) were assessed. Microphotography and quantitative analysis were performed using MoticImagesPlus 2.0. Statistical processing was carried out using the computer program Statistica.Results. It has been established that the combined administration of 974zh and Y. pestis EV leads to morphological and functional restructuring of immunocompetent organs, enhances the proliferation of plasma cells in the spleen and lymph nodes, and eliminates negative changes in the liver and adrenal glands. Conclusion. Thus, the 974zh preparation enhances the immunogenic effect of the Y. pestis EV vaccine strain, increasing the T- and B-dependent zones of the spleen and lymph nodes, increasing the proliferation of plasma cells, and also significantly reduces pathological changes in the liver and adrenal glands.

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Section: Infectious Diseases инфекционные болезни введениеunclassified

Structural rearrangement of organs of white mice vaccinated with Yersinia pestis EV in combination with organoselenium compound 974zh

Дубровина

Starovoytova

Юрьева

et al. 2022

Acta biomedica scientifica

Self Cite

View full text Add to dashboard Cite

show abstract

Prospects for the use of synthetic organoselenium compounds for the correction of metabolic and immune status during vaccination with live attenuated vaccines against especially dangerous infections

Abstract: Infectious diseasesИнфекционные болезни инфекционные болеЗни infeCtious diseases

Cited by 1 publication

References 40 publications

Structural rearrangement of organs of white mice vaccinated with Yersinia pestis EV in combination with organoselenium compound 974zh

Structural rearrangement of organs of white mice vaccinated with Yersinia pestis EV in combination with organoselenium compound 974zh

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