Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma

Izadpanah, Sama; Shabani, Parastoo; Aghebati‐Maleki, Ali; Baghbanzadeh, Amir; Fotouhi, Ali; Bisadi, Amir; Baradaran, Behzad

doi:10.1002/jcp.29344

Cited by 26 publications

(19 citation statements)

References 171 publications

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“…Despite this progress, curative treatment of OS remains challenging with subsequent poor prognosis and shortened life expectancy [ 3 ]. Early diagnosis and treatment of OS, particularly with nonmetastatic OS, is crucial for improving the prognosis of OS patients [ 4 ]. Unfortunately, few distinctive diagnostic and prognostic biomarkers have been identified.…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases

Cai

Lü

Yin

et al. 2021

BioMed Research International

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Osteosarcoma (OS) is a type of bone malignancy with a high rate of treatment failure. To date, few evident biomarkers for the prognostic significance of OS have been established. Oncomine was used to integrate RNA and DNA-seq data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and the published literature. The correlation of the gene Trophinin (TRO) and different types of cancers was generated using the Cancer Cell Line Encyclopedia (CCLE) online tool. Prognostic values of featured Melanoma Antigen Gene (MAGE) members were further assessed by establishing the overall survival using the Kaplan-Meier plotter. Moreover, the online tool, Database for Annotation, Visualization and Integrated Discovery version (DAVID), was used to understand the biological meaning list of the genes. MAGEB10, MAGED2, TRO, MAGEH1, MAGEB18, MAGEB6, MAGEB4, MAGEB1, MAGED4B, MAGED1, MAGEB2, and MAGEB3 were significantly overexpressed in sarcoma. TRO was further demonstrated to be distinctively upregulated in osteosarcoma cell lines and associated with shorter overall survival. TRO may play an important role in the development of OS and may be a promising potential biomarker and prognostic factor.

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Section: Introductionmentioning

confidence: 99%

[Retracted] Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases

Cai

Lü

Yin

et al. 2021

BioMed Research International

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“…The incidence of osteosarcoma recurrence and metastasis due to the failure of the conventional therapies is strictly related to the critical role of CSCs, presented in several tumours, that exhibit stem-like phenotype and high drug resistance suggesting their involvement in tumour invasiveness and metastasis frequently observed in osteosarcoma patients 15 . Moreover, the lack of predictive in vitro models of the real physio-pathological scenario leads to a poor clinical translation of many apparently promising drugs candidates but also to fail in deciphering the biological events.…”

Section: Discussionmentioning

confidence: 99%

Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche

Bassi

Panseri

Dozio

et al. 2020

Sci Rep

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The failure of the osteosarcoma conventional therapies leads to the growing need for novel therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population has been recently identified as the main limitation in the current therapies. Moreover, the traditional two-dimensional (2D) in vitro models, employed in the drug testing and screening as well as in the study of cell and molecular biology, are affected by a poor in vitro-in vivo translation ability. To overcome these limitations, this work provides two tumour engineering approaches as new tools to address osteosarcoma and improve therapy outcomes. In detail, two different hydroxyapatite-based bone-mimicking scaffolds were used to recapitulate aspects of the in vivo tumour microenvironment, focusing on CSCs niche. The biological performance of human osteosarcoma cell lines (MG63 and SAOS-2) and enriched-CSCs were deeply analysed in these complex cell culture models. The results highlight the fundamental role of the tumour microenvironment proving the mimicry of osteosarcoma stem cell niche by the use of CSCs together with the biomimetic scaffolds, compared to conventional 2D culture systems. These advanced 3D cell culture in vitro tumour models could improve the predictivity of preclinical studies and strongly enhance the clinical translation.

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“…They are considered to be mainly responsible for maintaining tumor cell vitality through self-renewal and infinite proliferation abilities, especially under hypoxia conditions [ 21 , 122 ]. Besides, CSCs are more resistant to conventional chemotherapy/radiotherapy and even latest immunotherapy [ 120 ], which may contribute toward cancer treatment failure and worsening of patients’ prognosis [ 123 , 124 ].…”

Section: Regulatory Network Of Lncrnas and Wnt Signaling Pathway In Osteosarcomamentioning

confidence: 99%

“…Drug resistance remains a multifaceted obstacle in cancer treatment, which may be attributed to tumor heterogeneity, survival pathway activation, and cytotoxic drug efflux [ 40 ]. Osteosarcoma patients often develop drug resistance, which may in turn largely impairs the therapeutic effect of chemotherapy, and eventually leads to tumor recurrence [ 124 , 129 ]. It is necessary to undermine the mechanisms in osteosarcoma chemoresistance, and thus to provide innovative strategy for efficacy improvement in chemotherapy.…”

Section: Regulatory Network Of Lncrnas and Wnt Signaling Pathway In Osteosarcomamentioning

confidence: 99%

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Lin

Liu

et al. 2021

Cancer Cell Int

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Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.

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Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma

Cited by 26 publications

References 171 publications

[Retracted] Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases

[Retracted] Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases

Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

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