Prospects for malaria control through the genetic manipulation of its vectors

Collins, Frank H.

doi:10.1016/0169-4758(94)90221-6

Cited by 37 publications

(23 citation statements)

References 4 publications

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“…Thus, only some parasites are able to develop and escape unharmed from the mosquito. A detailed understanding of the mechanisms involved in Plasmodium killing and the determination of mosquito permissiveness to malaria infection can be used for the development of novel malaria control strategies (Collins, 1994;Dimopoulos, 2003).…”

Section: Introductionmentioning

confidence: 99%

Plasmodium berghei ookinetes induce nitric oxide production in Anopheles pseudopunctipennis midguts cultured in vitro

Herrera-Ortíz

Lanz‐Mendoza

Martínez-Barnetche

et al. 2004

Insect Biochemistry and Molecular Biology

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Section: Introductionmentioning

confidence: 99%

Plasmodium berghei ookinetes induce nitric oxide production in Anopheles pseudopunctipennis midguts cultured in vitro

Herrera-Ortíz

Lanz‐Mendoza

Martínez-Barnetche

et al. 2004

Insect Biochemistry and Molecular Biology

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“…Interruption of either cycle would attenuate the spread of the disease. The prospect of control strategies based on transmission blocking in the vector (1,2) has energized studies on the molecular genetics of Anopheles gambiae. Special attention has been directed toward the main organs with which the parasite interacts during its development in the mosquito, the midgut and the salivary glands (3)(4)(5)(6).…”

mentioning

confidence: 99%

Anopheles gambiae pilot gene discovery project: Identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines

Dimopoulos

Casavant

Chang

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

143

105

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Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite limited. We have conducted a pilot gene discovery project to accelerate progress in the molecular analysis of vector biology, with emphasis on the mosquito's antimalarial immune defense. A total of 5,925 expressed sequence tags were determined from normalized cDNA libraries derived from immune-responsive hemocyte-like cell lines. The 3,242 expressed sequence tag-containing cDNA clones were grouped into 2,380 clone clusters, potentially representing unique genes. Of these, 1,118 showed similarities to known genes from other organisms, but only 27 were identical to previously known mosquito genes. We identified 38 candidate genes, based on sequence similarity, that may be implicated in immune reactions including antimalarial defense; 19 of these were shown experimentally to be inducible by bacterial challenge, lending support to their proposed involvement in mosquito immunity.

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“…First, those that render populations vulnerable to subsequent control measures, such as insecticide susceptibility or temperature sensitivity, and second, those that interrupt disease transmission by replacing vector with non-vector forms (Crampton et al 1990, Kidwell & Ribeiro 1992, Crampton 1994. Although many technical, and perhaps ethical, problems associated with the wild-release of transgenic insects have yet to be overcome, the potential of this technology has received greater attention recently (Brey 1991, Coluzzi 1992, Collins 1994, Curtis 1994. Introduction and expression of genes coding for antibodies against target antigens present on the ookinete surface into the mosquito embryos is one of the possibilities to examine the potential of this technology (Crampton et al 1993).…”

Section: Factors Affecting Parasite Development To the Mosquitomentioning

confidence: 99%