Prospects for Drugs Based on the Mitochondria-Targeting Antioxidant SkQ1 in Treatment of Wounds with Impaired Healing

Zinovkin, Roman A.; Попова, Е. Н.; Плетюшкина, О.Ю.; Ильинская, О. П.; Писарев, В. М.; Черняк, Б.В.

doi:10.15360/1813-9779-2018-2-69-86

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Высокоэффективный митохондриальнонаправленный антиоксидант SkQ1 стимулирует заживление кожных ран, действуя на воспалительную и пролиферативную фазы ранозаживления в различных экспериментальных моделях in vivo и in vitro. Имеются основания полагать, что препараты для локальной терапии труднозаживающих ран на основе SkQ1 послужат эффективным средством борьбы с длительно незаживающими ранами у разных категорий пациентов, в том числе при сахарном диабете, а также у пациентов с хроническими критическими состояниями и рецидивирующими инфекциями [27].…”

Section: лечение хронических ран митохондриальнонаправленные антиокси...unclassified

The role of mitochondria in the pathogenesis of the "complex" wound process

Супильников

Ledovskikh

Dzhamalova

et al. 2022

vmirvz

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Wound healing is a complex biological process involving various cells, mediators, and components of the extracellular matrix involved in the processes of coagulation, inflammation, angiogenesis, epithelialization, and fibroplasia. Wound healing is described by four interrelated phases: hemostasis, inflammation, proliferation and remodeling. Each of the phases has its role at the molecular and tissue levels, and if a defect occurs in the chain of one of the phases of the wound healing process, the healing process is disturbed and a chronic wound condition occurs. Various factors such as infections, arterial and venous circulatory disorders, type 2 diabetes and chronic inflammation contribute to this. Prolonged non-healing wounds represent an urgent problem of modern medicine. Oxidative stress plays a crucial role in the pathogenesis of chronic wounds. In this review the pathogenesis of chronic wounds and its involvement of reactive oxygen species (ROS), oxidative stress, the role of mitochondria in ROS generation as well as the prospects of mitochondrial-directed antioxidants in the treatment of chronic wounds are considered.

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Section: лечение хронических ран митохондриальнонаправленные антиокси...unclassified

The role of mitochondria in the pathogenesis of the "complex" wound process

Супильников

Ledovskikh

Dzhamalova

et al. 2022

vmirvz

View full text Add to dashboard Cite

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Development of Wound Dressing for Regenerative Medicine

Kudryashova

Markov

Kostromina

et al. 2021

Bulletin of Rehabilitation Medicine

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The understanding of the pathophysiological mechanisms of the wound process deepened with the development of science. The technological base that was creating has enabled to serve the clinical needs of tissue repair. These factors, combined with the growing need for healing of infected and chronic wounds, have led to the expansion of the market for wound dressings materials supplies. In this connection, there is a need to generalize and update information about new types of dressings. This review provides an up-to-date understanding of the wound process: cellular and signaling mechanisms of repair, characteristics of the optimal microclimate of the wound bed, morphofunctional re-arrangements of tissues during the healing process. Based on these data, the requirements for the modern wound dressings are formulated. Existing wound dressings have been classified as interacting with body tissue. The bio-functional characteristics of the synthetic and natural polymers used in the dressing are described, including their effect on regenerative processes. A classification of the active medicinal ingredients used in the manufacture of dressings is given, the characteristics of their use on the background of the pathological wound process are considered.

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Prospects for Drugs Based on the Mitochondria-Targeting Antioxidant SkQ1 in Treatment of Wounds with Impaired Healing

Cited by 2 publications

References 35 publications

The role of mitochondria in the pathogenesis of the "complex" wound process

The role of mitochondria in the pathogenesis of the "complex" wound process

Development of Wound Dressing for Regenerative Medicine

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