2000
DOI: 10.1086/313687
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Prospects for Control of Herpes Simplex Virus Disease through Immunization

Abstract: Herpes simplex viruses (HSVs) can cause a variety of infections, including genital herpes. Despite effective antiviral therapy, HSV infections remain a significant worldwide public health problem. Vaccines offer the best hope for controlling spread and limiting HSV disease. This article discusses the pathogenesis and immunobiology of mucocutaneous HSV infections, summarizes the spectrum of diseases caused by HSV, and provides a review of the field of HSV vaccine research. This article also discusses what might… Show more

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Cited by 174 publications
(115 citation statements)
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“…Numerous studies demonstrated that sexually transmitted infections (STIs) enhance susceptibility to HIV-1 acquisition and transmission, even in the absence of clinical symptoms (1)(2)(3)(4)(5). The most common viral STI acquired during sexual contact in the developing world is genital herpes (6), which is primarily caused by HSV type 2 (HSV-2), although HSV type 1 infection can also lead to genital herpes (7). Pre-existing HSV-2 infection is a risk factor for acquiring HIV-1 infection through sexual contact (1)(2)(3)(4).…”
mentioning
confidence: 99%
“…Numerous studies demonstrated that sexually transmitted infections (STIs) enhance susceptibility to HIV-1 acquisition and transmission, even in the absence of clinical symptoms (1)(2)(3)(4)(5). The most common viral STI acquired during sexual contact in the developing world is genital herpes (6), which is primarily caused by HSV type 2 (HSV-2), although HSV type 1 infection can also lead to genital herpes (7). Pre-existing HSV-2 infection is a risk factor for acquiring HIV-1 infection through sexual contact (1)(2)(3)(4).…”
mentioning
confidence: 99%
“…Reduced viral load in vaccinated individuals may also reduce transmission as has been observed previously with antiviral drugs [8]. Indeed, studies reviewed recently by Stanberry et al suggest that prior exposure to HSV-1 may provide some protection from acquisition of genital HSV-2 infection and limits the severity of the disease as compared to HSV-1 naive individuals [21]. A similar effect was observed in HSV-2 seropositive individuals in that reinfection by a second strain of HSV-2 is infrequent [7].…”
Section: Introductionmentioning
confidence: 80%
“…Among the human herpesviruses, herpes simplex virus types 1 and type 2 (HSV-1 and -2, respectively) are most closely related and share significant DNA sequence homology (15,31,32). Although HSV infections are often asymptomatic, their clinical manifestations include oral-facial infections, genital herpes, neonatal herpes, keratoconjunctivitis, and herpes encephalitis (48,54). Despite the availability of various effective antiviral therapies, the spread of genital herpes infection continues to increase worldwide and has increased by 30% in the United States in the past two decades (19).…”
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confidence: 99%
“…Despite the availability of various effective antiviral therapies, the spread of genital herpes infection continues to increase worldwide and has increased by 30% in the United States in the past two decades (19). The failure of antiviral therapy in effectively controlling the spread of HSV disease and the life-long nature of the infection present a strong need for developing safe and efficacious vaccines against HSV infections (48,54).…”
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confidence: 99%
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