Prospects and Challenges for Translating Emerging Insights in Plant Chemical Biology into New Agrochemicals

Walsh, Terence A.

doi:10.1002/9781118742921.ch7.1

Cited by 2 publications

(2 citation statements)

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“…In recent years, plant scientists have successfully used ‘chemical tools’ to address fundamental questions about plant biology, such as intracellular transport processes, cell wall biology, and plant hormone signalling (reviewed in [ 1 ]). These synthetic molecules have the potential to be developed as agrochemical leads, while vice versa, the research on agrochemicals has generated plant chemical biology knowledge and tools for basic research [ 12 ].…”

Section: Eu-openscreen and The Resistance Challenge In Agriculturementioning

confidence: 99%

“…by mimicking plant hormones and priming plant defence responses to elicit protection against fungal and bacterial pathogens or insect pests. Besides crop-protective substances, chemical compounds can also be used as plant growth regulators for plants and yield improvement by inducing favourable phenotypes [ 12 ]. One example is compounds that interfere with ethylene responses and have a useful application in the post-harvest quality of fruits and vegetables [ 13 ].…”

Section: Eu-openscreen and The Resistance Challenge In Agriculturementioning

confidence: 99%

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EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms

2014

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EU-OPENSCREEN is an academic research infrastructure initiative in Europe for enabling researchers in all life sciences to take advantage of chemical biology approaches to their projects. In a collaborative effort of national networks in 16 European countries, EU-OPENSCREEN will develop novel chemical compounds with external users to address questions in, among other fields, systems and network biology (directed and selective perturbation of signalling pathways), structural biology (compound-target interactions at atomic resolution), pharmacology (early drug discovery and toxicology) and plant biology (response of wild or crop plants to environmental and agricultural substances). EU-OPENSCREEN supports all stages of a tool development project, including assay adaptation, high-throughput screening and chemical optimisation of the ‘hit’ compounds. All tool compounds and data will be made available to the scientific community. EU-OPENSCREEN integrates high-capacity screening platforms throughout Europe, which share a rationally selected compound collection comprising up to 300,000 (commercial and proprietary compounds collected from European chemists). By testing systematically this chemical collection in hundreds of assays originating from very different biological themes, the screening process generates enormous amounts of information about the biological activities of the substances and thereby steadily enriches our understanding of how and where they act.

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Section: Eu-openscreen and The Resistance Challenge In Agriculturementioning

confidence: 99%

Section: Eu-openscreen and The Resistance Challenge In Agriculturementioning

confidence: 99%

EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms

2014

View full text Add to dashboard Cite

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High throughput selection of novel plant growth regulators: Assessing the translatability of small bioactive molecules from Arabidopsis to crops

et al. 2016

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Plant growth regulators (PGRs) have become an integral part of agricultural and horticultural practices. Accordingly, there is an increased demand for new and cost-effective products. Nevertheless, the market is limited by insufficient innovation. In this context chemical genomics has gained increasing attention as a powerful approach addressing specific traits. Here is described the successful implementation of a highly specific, sensitive and efficient high throughput screening approach using Arabidopsis as a model. Using a combination of techniques, 10,000 diverse compounds were screened and evaluated for several important plant growth traits including root and leaf growth. The phenotype-based selection allowed the compilation of a collection of putative Arabidopsis growth regulators with a broad range of activities and specificities. A subset was selected for evaluating their bioactivity in agronomically valuable plants. Their validation as growth regulators in commercial species such as tomato, lettuce, carrot, maize and turfgrasses reinforced the success of the screening in Arabidopsis and indicated that small molecules activity can be efficiently translated to commercial species. Therefore, the chemical genomics approach in Arabidopsis is a promising field that can be incorporated in PGR discovery programs and has a great potential to develop new products that can be efficiently used in crops.

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Prospects and Challenges for Translating Emerging Insights in Plant Chemical Biology into New Agrochemicals

Cited by 2 publications

References 61 publications

EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms

EU-OPENSCREEN—chemical tools for the study of plant biology and resistance mechanisms

High throughput selection of novel plant growth regulators: Assessing the translatability of small bioactive molecules from Arabidopsis to crops

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